The implications of poor sleep quality on arterial health in persons with multiple sclerosis

Brooke M. Shafer; Sushant M. Ranadive; Tracy Baynard; Robert W. Motl; Bo Fernhall

doi:10.1016/j.artres.2017.06.005

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Volume 19, Issue C, September 2017, Pages 49 - 55

The implications of poor sleep quality on arterial health in persons with multiple sclerosis

Authors

Brooke M. Shafer^a, Sushant M. Ranadive^b, Tracy Baynard^a, Robert W. Motl^c, Bo Fernhall^a^{, *}

^aDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, United States

^bDepartment of Anesthesiology, Mayo Clinic, Rochester, United States

^cDepartment of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, United States

^*Corresponding author. Department of Kinesiology and Nutrition, University of Illinois at Chicago, 808 S. Wood, Room 169, Chicago, IL 60612, USA. E-mail address: fernhall@uic.edu (B. Fernhall).

Corresponding Author

Bo Fernhall

Received 12 December 2016, Revised 8 June 2017, Accepted 23 June 2017, Available Online 10 July 2017.

DOI: 10.1016/j.artres.2017.06.005 How to use a DOI?
Keywords: Multiple sclerosis; Sleep quality; Arterial function
Abstract: Background: Multiple sclerosis (MS) is associated with increased risk of cardiovascular disease (CVD) and approximately 25–54% of patients report poor sleep quality. There is evidence from the general population of an association between poor sleep and increased CVD risk, but this is poorly understood in MS.

Purpose: This study examined the association between self-reported sleep quality and arterial health in persons with MS.

Methods: MS subjects (n = 31) and control subjects (n = 23) were recruited. Control subjects were age and body size matched. All subjects were administered the Pittsburgh Sleep Quality Index (PSQI) to assess self-reported sleep quality. Subjects with a global score >5 were classified as “poor sleepers”. Blood pressure, arterial stiffness, and the forearm blood flow responses following 5-min ischemic occlusion (endothelial function) were measured.

Results: Nineteen MS subjects and 5 control subjects were classified as “poor sleepers”. AIx was significantly higher in MS subjects who had poor sleep quality (32.5 ± 8.8 vs 22.0 ± 13.2; P < 0.05).

Conclusions: Markers of arterial dysfunction were significantly higher in MS subjects with poor sleep quality compared to those with good sleep quality. This study suggests novel evidence for the association of CVD risk and sleep quality in MS.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 19 - C
Pages: 49 - 55
Publication Date: 2017/07/10
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2017.06.005 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - Brooke M. Shafer
AU  - Sushant M. Ranadive
AU  - Tracy Baynard
AU  - Robert W. Motl
AU  - Bo Fernhall
PY  - 2017
DA  - 2017/07/10
TI  - The implications of poor sleep quality on arterial health in persons with multiple sclerosis
JO  - Artery Research
SP  - 49
EP  - 55
VL  - 19
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.06.005
DO  - 10.1016/j.artres.2017.06.005
ID  - Shafer2017
ER  -

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