Although, Ginseng and Codonopsis belonged to different genus, they were similar in thekjh medicinal properties, pharmacological effects and other aspects, and even someone was forward that the ancient Ginseng was today's Codonopsis. As the price of Ginseng was much higher, Codonopsis was often used to...

Quinazoline derivatives have been shown to be biologically active such as afatinib. The cinnamic acid derivative is an important part of the quinazoline derivative which exerts its activity. And Cinnamic acid derivatives were prepared by the benzaldehyde derivatives and malonic acids. In this paper,...

Either the alveolar bone defects or the severe absorbed alveolar bone led by the teeth extraction could have an effect on the orthodontic teeth movement. Guided bone generation technique has supplied a new method for the above clinical difficulty. Platelet-Rich Fibrin has been reported in the orthodontics...

4-Chloro-6-methoxy-2-methyl-3-nitroquinoline (1) was synthesized from 4-methoxyaniline through three steps including Cyclization, Nitrification and Chlorination. The structure of the target product (1) was confirmed by 1H NMR and MS. This method started with cheap raw materials was of simple experimental...

2-((4-substituted phenyl) amino) benzaldehyde, is an important intermediate for the synthesis of many biologically active intermediates of anticancer drugs. In this work, a rapid and high efficiency synthetic method for compound 1a-1b was established. Compound 1a-1b was synthesized from 2-chloronicotinic...

Sorafenib (1) in the medical field to show the potential biological activity. Literature on the majority of tumor cells have a high biological activity, such as lymphoma, breast cancer, prostate cancer. However, some synthetic route of Sorafeni has disadvantages, such as low product yield and complicated...

Thieno[2,3-d]pyrimidine is a key intermediate in many biologically active compounds such as GDC-0941 and BKM 120. In this work, a rapid synthetic method for compound (4) was established. The compound (4) was synthesized from the commercially available methyl 2-aminothiophene-3-carboxylate and formimidamide...

4-(Thieno[3,2-d]pyrimidin-4-yl)morpholine derivatives is an important intermediate which inhibited tumor necrosis factor alpha and nitric oxide. In this work, a rapid and green synthetic method for compound (5) was established. The compound (5) was synthesized from the commercially available methyl 3-aminothiophene-2-carboxylate...

1-(2-(piperidin-1-yl)ethyl)-1H-pyrrole-2-carbaldehyde 4a-b is a new aqueous solubility aldehyde as an important intermediates of small molecule anticancer drugs. In this work, a rapid synthetic method for target compounds 4a-b was established. The compound 4a-b was synthesized from the commercially available...

Afatinib (1) exhibited potential biological activities in medicine. There are shortcomings in the synthesis route of afatinib in the literature, the product yield is low and the post-processing is complicated. Therefore, in this paper, the two-step synthetic route of afatinib was optimized. The two-step...

3-phenyl-1H-pyrazole (1) is an important intermediate for the synthesis of many biologically active compounds. It was synthesized from acetophenone (2) and hydrazine through two steps including Knoevenagel condensation, Cyclization reaction reaction. In this paper, three novel 3-phenyl-1H-pyrazole derivatives...

Chalcone is an important intermediate in many biologically active compounds such as flavonoid. Chalcone was prepared by the aldol condensation of benzaldehyde with acetophenone. In this paper, five novel chalcone derivatives were prepared. The structure were confirmed by MS and 1H NMR. Furthermore, the...

2-Chloronicotinic acid and its derivatives are important intermediates for the synthesis of medical antibiotics, anti-cardiovascular drugs, insecticides and herbicides, and they used in the synthesis pranoprofen and diflufenican. In this work, a rapid synthetic method for 2-morpholinonicotinic acid was...

Objective To investigate the expression of beta-adrenergic receptor( -AR) in glioma cells and the effect of blocking -adrenergic receptors on glioma cell proliferation. Methods: The expression of beta-adrenergic receptor in glioma LN229 and U251 cells were detected by real time PCR and Western Blotting....

Chronic bronchitis is a common and frequent disease of respiratory system in the clinical; its main manifestation is the chronic non-specific inflammation of trachea, bronchial mucosa and surrounding tissue; its etiology is complex, associating with infection, allergies, genetic, immune dysfunction and...

Also known as the starter motor or starter motor, the main role is that the electric energy of battery is converted into mechanical energy to drive the engine flywheel rotating, thus starting the engine.This paper is Electromagnetic soft starter meshing and Engine for gas engine.The main parts of the...

Castleman's disease (CD) is a chronic lymphoproliferative disorder characterized by unexplained enlarged lymph nodes. CD of the tracheal is rare, and shows unspecific manifestation with high misdiagnosis rate. Here we reported a case of tracheal CD in a 43-year-old female. Finally, the nodule of the...

In this paper, zebrafish was used as a model organism to study the toxicity of beta cypermethrin with different concentration gradient on the whole zebrafish, and the effects on superoxide dismutase (SOD) and peroxidase (POD) activities of zebrafish brain tissue. As a result, was found among the mortality...

Tert-Butyl 5-amino-4 - ((2-(dimethyl- amino) ethyl) (methyl) amino) -2- methoxyphenyl) carbamate (1) is an important intermediate in many biologically active compounds such as omisertinib (AZD9291). In this work, a rapid synthetic method for compound 1 was established. The compound 1 was synthesized...