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6-Bromo-4-iodoquinoline is an important intermediate for the synthesis of many biologically active compounds, such as GSK2126458. It was synthesized from 2,2-dimethyl-1,3- dioxane-4,6-dione and 4-bromoaniline through five steps including cyclization reaction and substitution reaction. And the structures...

7-(Benzyloxy)-4-chloro-6-methoxyquinazoline(1) was synthesized from methyl 4-hydroxy-3-methoxybenzoate(2) through five steps including substitution,nitration,reduction,cyclization and chlorination.Its structure was confirmed by 1 H NMR and MS spectrum.The total yield of the five steps was 29.2%.

A novel N, N-(4-amino phenyl maleimide) diglycidyl amine (APMDGA) was synthesized from maleic anhydride, 4-nitroaniline, and epichlorohydrin by a few-step reactions via intermediate products N-(4-nitrophenyl)maleimide and N-(4-aminophenyl)maleimide. The chemical structure of APMDGA is confirmed by 1H-NMR,...

Amphiphilic carboxyl-terminated Hyperbranched Polyester (c-HBPE) is synthesized by 1,2,4-Benzenetricarboxylic anhydride BTAA and 1,6-hexanediol. The structure of c-HBPE is characterized by FT-IR, 1H-NMR, GPC. Vesicles of c-HBPE are fabricated by aqueous self-assembly. Results of Transmit-tance Measurement(TM),...

An amphiphilic RAFT agent was synthesized, which could polymerize with monomers as Reversible Addition-Fragmentation Chain Transfer Polymerization route. The resulting RAFT agents were characterized by FT-IR and 1H NMR. The dispersing ability of synthesized RAFT agent was evaluated. Organic phthalocyanine...

Cyclohexanone pentaerythritol ketal was synthesized from cyclohexanone and pentaerythritol by condensation using NaHSO4 as catalyst and characterized by NMR and MS spectrum. Furthermore, the structure of the tile compound was confirmed by single-crystal X-ray diffraction. It crystallizes in orthorhombic...

In order to improve the accuracy of groundwater detection, the forward problem of NMR response in three-dimensional is discussed in this paper. The three-dimensional magnetic field equations and boundary conditions in frequency domain with the loop source are derived by Maxwell's equations and then the...

With the growth in manufacturing value added (MVA), Indonesia occupies the highest position in ASEAN. Indonesia’s MVA reached 4.84 percent, while in ASEAN it was around 4.5 percent, then at the global level it was ranked 9th in the world. From the manufacturing sector, Indonesia is in the top five in...

A terpolymer resin (NSMA) was synthesized with styrene, maleic anhydride and N-phenyl maleimide. The structure and composition was characterized with FT-IR and 13C-NMR. The thermal resistance of NSMA was determined through integrated thermal analysis. The results indicated that, when the molar ratio...

In the process of fluvial reservoirs development, bottom water coning leads to the problem of increasing water cut and low oil production. There are still significant amount of remaining oil in the upper layers of reservoirs after long-term waterflood. Drilling one or more lateral drainholes near the...

The principle of constant gradient field NMR is same with the logging expert system, the state-of-the -art technology in the world, wherein, gradient design and 2D spectrum inversion algorithm are adopted to quicken the instrument measurement speed while the diffusion coefficients of a fluid can be measured...

The conversion of progesterone (1) by Aspergillus sp. was studied. The major metabolites formed from progesterone were identi ed as 11 -hydroxyl progesterone (2), 15 -hydroxyl progesterone (3), 15 -hydroxypreg-1,4-dien-3,20-dione (4), 6 ,11 -dihydroxypregesterone (5).Conversion products were characterized...

A symmetrical Gemini cationic asphalt emulsifier of 1,3-bis(3'-coconut oil amide propyl-dimethyl ammonium chloride)-2-hydroxy propane was synthesized by two steps reaction of coconut oil acyl propyl dimethyl tertiary amine (PKO), epoxy chloropropane and hydrochloric acid. The structure of the product...

A novel thiopyrano[4,3-d]pyrimidine derivative compound 1 was synthesized with methyl dimethyl 3,3'-thiodipropionate as starting material through five steps, including cyclization, chlorination, substitution with morpholine and coupling with 5-bromopyridin-2-amine through Suzuki reaction. And its structure...

A novel thiopyrano[4,3-d]pyrimidin derivative bearing a indole-hydrazone was synthesized and structure was confirmed by 1H NMR and MS. Moreover, this compound was evaluated for its cytotoxicity against the H460 cell lines and inhibitory activity against mTOR kinase at a concentration of 10uM. The result...

The correlated X-ray scattering (CXS) was introduced and compared with other methods which were used to study the structures of the biomacromolecules in solution, such as nuclear magnetic resonance (NMR), electron microscope (EM) and small-angle x-ray scattering (SAXS). Then a key step which was used...

1. Objective: To improve the synthetic procedure of the anticancer drug poziotinib. 2. Methods: The poziotinib was synthesized in six stages starting from 7-methoxy-4-oxo-3,4-dihydroquinazolin-yl acetate (2) by chlorinated, ammonification, hydrolysis, condensation, take off Boc and amidation reaction....

3-Morpholin-4-yl-1-(4-nitrophenyl)-5,6-dihydro-1H-pyridin-2-one (1) is an important intermediate for the synthesis of many biologically active compounds. It was synthesized from cyclopentanone oxime (7) and 1-fluoro-4-nitrobenzene through three steps including rearrangement Reaction, condensation and...

Five kinds of Brønsted-acidic ionic liquids with different nitrogen-contained chemical groups and different anions were synthesized, and were respectively characterized by nuclear magnetic resonance(NMR), infrared spectrum (IR), electrospray ionization mass spectrum (ESI-MS) and thermogravimetry(TG....

The main contents of clove oil are phenolic compounds, namely eugenol, eugenol acetate and gallic acid, as well as flavonoids. One of the derivatives of the eugenol compound is acetyl eugenol which was developed by the esterification reaction between eugenol and acetic acid anhydride using the sonochemical...

The binary systems Eu(L)3(ClO4)3∙2H2O and ternary systems EuL3(CD)3∙2H2O were synthesized. The structural features of the systems were analyzed. The composition and structure of the synthesized complex compounds were studied by NMR spectroscopy, IR spectroscopy, X-ray phase analysis, thermal analysis,...

Several SO3H-functionalized acidic ionic liquids (ILs) were synthesized by two-step method, using 1, 3-propane sulfone and 1, 4-Butanesultone as raw materials, respectively. It is noteworthy that the ionic liquid using 2-ethyl-4-methylimidazole as source has not been reported. Esterification of 1-butanol...

Hexagonal spindle-shaped mesoporous alumina was prepared using Al-based metal-organic frameworks (MOFs) MIL-96 as precursor through thermal treatment method. The MIL-96 and alumina products were characterized by XRD, SEM, BET and 27Al-NMR. Results from these characterizations showed that alumina products...

Melanin LEM236 was extracted and purified from Lachnum YM-236. Scanning electron microscopy showed LEM236 had a blocky, amorphous crystal structure with an irregular surface. Elemental analysis, infrared spectroscopy and 1H-NMR measurements indicated that the melanin had the structure model of a novel...

This work introduces tow solid-state 13C Nuclear Magnetic Resonance(NMR) methods, cross polarization- total suppression of sidebands/magic angle spinning (CP-TOSS/MAS) and direct polarization/magic angle spinning (DP/MAS), for detecting chemical structure of coal combustion emissions. The CP-TOSS/MAS...

Concrete as a widely used construction material, exhibits particular importance in terms of durability under extreme environmental conditions, especially under the effects of wet-dry cycles and sulfate corrosion. This study focuses on concrete made from various proportions of desert sand and manufactured...

6,4’’-Di-O-methylerythromycin A is a relative substance of clarithromycin, which is due to incomplete protection of 4’’-OH during the methylation process. In this study, 6,4’’-Di- O-methylerythromycin A(5) and its derivatives including 2’-O-TMS-6-O-methylerythromycin A 9-[(1-ethoxy-1-methylethyl)oxime](2),...

“Antibiotics golden era” can end when resistant strains spread immensely. To find new anti-infective agents, we examined sea cucumber associated bacteria isolated from the intestinal part of the echinoderm Holothuria leucospilota. Partial identification using 16S rRNA gene Sanger sequencing revealed...

Photoresponsive materials have attracted much attention recently because of their potential utility in many areas such as industrial, agricultural and pharmaceutical. In this paper, several photoresponsive biopolymers having spiropyran and chitosan groups were synthesized, and the structure and properties...

Multi-drug resistance (MDR) is an important element which leads to ineffectiveness of chemotherapeutics. The discovery of histone acetylase’s unusual activities in tumor cells provides a new area for the cure of cancer. And histone deacetylases inhibitor (HDACi) is used as a new agent in clinical therapy....

Seven novel 3'-mono-substituted chalcone derivatives were synthesized from 2,4-dihydroxyacetophenone in 4 steps in 18-31% overall yield. Their structures were confirmed by 1H NMR. The anticancer activity of these new target compounds (4~10) against human leukemia K562 cells were evaluated by MTT assay...

In order to study the mechanism of shear strength deterioration of soil-rock mixtures under frost-thaw action, the frost-thaw soil-rock mixtures were studied by nuclear magnetic resonance (NMR) and triaxial shear tests. The results show that the shear strength deterioration of soil-rock mixtures with...

A novel spirocyclic halogen-free ame retardant ISCP was successfully synthesized, and its structure was confirmed by FTIR, 1H NMR, and 31P NMR. Results of LOI, UL-94, and CONE tests demonstrated that the ISCP effectively enhanced flame retardancy of EP composites, which could improve the LOI value from...

Amide tautomer imidic acid were exit, which proved by NMR spectra characterization. The protein BSA was test by 1H NMR in different pH values solutions, to show the different amide/imidic acid structures exit in BSA. The amide/imidic-acid unit with H proton communication might be the biological protein...

In this paper, a series of polyimide films were prepares through a novel precursor pre-imidized poly (amic acid) ammonium salt (PI-PAAS). The chemical structure of PI-PAAS films was confirmed by 1H NMR, and the degree of pre-imidization was confirmed by FT-IR spectra. And the intrinsic viscosity of the...

The biotransformation of digoxigenin by Colletotrichum lini AS3. 4486 was investigated. The conversion reaction was carried out in a 72h process, and the sole products was isolated by column chromatography and elucidated as digoxigenone by HR-ESI-MS, 1H-NMR , 13C-NMR and single–crystal X-ray diffraction....

(-)-Dibornyl oxalate was synthesized by the reaction of natural (-)-borneol with oxalyl chloride under the optimized reaction conditions: temperature 35 , time 1 h and the molar ratio of (-)-borneol and oxalyl chloride 1.0 : 0.6. The reaction underwent in good selectivity as 99 % for target product which...

A new approach for preparing polycaprolactone (PCL) with functional groups was introduced, by which three kinds of functional group-terminated PCLs (PCL-OH, PCL-Boc and PCL-NH2) were designed and synthesized. The composition, structure, and thermal property of these functional PCLs were characterized...

Within soil-rock mixtures, there exist numerous pores, and under the action of seepage, particles migrate along internal pore channels, leading to structural damage and disasters such as dam collapses and landslides. In practical situations, pore development under seepage often occurs under complex stress...

1-(4-Bromo-2-fluorophenyl)-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one (1) is an important intermediate for the synthesis of many biologically active compounds. It was synthesized from pyridin-4-ol (7) and 4-bromo-2-fluoroaniline through five steps including nitration, chlorination, N-alkylation, reduction...

Schiff base compounds are reported to have various biological activities, one of which is antibacterial. This study aims to determine the characterization of the Schiff base product with the sonication method and to determine its antibacterial activity. Schiff base products from 4formylpyridine and panisidine...

Poly(L-lactide-co-morpholine-2,5-dione) (PLAMD) was synthesized via ring-opening polymerization (ROP) of morpholine-2,5-dione and L-lactide using stannous octoate as initiator. Poly(L-lactide-co-morpholine-2,5-dione) was characterized by means of 1H NMR, FTIR spectrum and gel permeation chromatography...

In this paper, a novel poly(N-propionyl-L-aspartic acid-co-1,3-propylene glycol) (PPAP) was successfully synthesized with L-aspartic acid and 1,3-propylene glycol. The chemical structure of poly(N-propionyl-L-aspartic acid-co-1,3-propylene glycol) was characterized by FTIR and 1H NMR spectrum. The UV...

In this paper, we used L-aspartic acid, dimethyl tartrate and propionic anhydride as raw materials to prepare a new thermo-sensitive poly(N-propionyl-L-aspartic acid-co-dimethyl tartrate) (PPADT). The chemical structures of the intermediates, monomer and polymer have been confirmed by FTIR and 1H NMR...

Fundamental organic chemistry is a compulsory course for college students major in chemistry. It is very difficult for teachers attracting students’ attention for long term study on the basis of the current teaching system. We introduce scientific research achievements, frontier knowledges and hot research...

Eutectic Based Ionic Liquids (EILs) are a new alternative to conventional ionic liquids which are considered cheaper, more environmentally friendly and biodegradable for use as a solvent in the chemical process of lignin. The aim of this research is to study the chemical process of lignin dissolution...

Anthocyanins are one of the most important water-soluble pigments in the nature. Interests in the research of anthocyanins are increasing due to its nutritional value and biological activity. Extraction, separation and qualitative and quantitative analysis of anthocyanins are indispensable and important...

In the recent years, using CO2 injection into oil reservoirs to enhanced oil recovery (CO2-EOR) has attracted more and more attention from industry and laboratory experiment. The mass transfer and diffusion of CO2 in oil is one of the key parameters of displacement process. In this study, by employing...

4-(4'-quinazolin-ylamino) phenyl-4-(N,N- dimethylamino) phenyl propenyl ketone with total yield of 68.0% was synthesized with 2-aminobenzonitrile and N,N-dimethylformamide dimethyl acetal as a starting material, the synthesis of N-(2-cyanophenyl)-N,N-dimethyl formami- dine, and then amino acetophenone...

Modernization of Chinese medicine is inseparable from modern, efficient separation and analysis techniques. The development of modern analytical techniques, especially the emergence of chromatography technology has accelerated the pace of traditional Chinese medicine research and development. The technology...