Artery Research

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Volume 3, Issue 4, December 2009, Pages 171 - 171

P4.06 DIFFERENTIAL EFFECTS OF NEBIVOLOL AND ATENOLOL ON CAROTID ARTERIAL WAVE INTENSITY

Authors
C. Park, J. Sever, A.W. Khir, C.L. Chang, S. Thom, A.D. Hughes, N. Poulter
Imperial College London, London, United Kingdom
Available Online 3 December 2009.
DOI
10.1016/j.artres.2009.10.047How to use a DOI?
Abstract

Background The hemodynamic effects of the vasodilator β-blocker nebivolol may differ from those of a conventional agent. Wave intensity analysis can describe the energy transported by wavefronts in the arterial system in the direction of wave propagation. A non-invasive ultrasound-based technique [1] was used to compare the effects of nebivolol and atenolol on carotid arterial wave intensity in patients participating in a hypertension treatment study.

Methods 38 hypertensive patients (age 63±11yrs, 21 female) took part in a double-blind randomised cross-over study. All received bendroflumethazide 2.5mg for 6 weeks in advance, and throughout the study. We compared effects of nebivolol 5mg and atenolol 50mg on the magnitude of the initial systolic forward compression wave (S), the protodiastolic forward decompression wave (D) (both generated by the heart), the reflected compression wave (c−1) and local wave speed.

Results. The S and D waves were significantly smaller with atenolol than with nebivolol treatment but wave reflection and wave speed did not differ.

Wave parameter Nebivolol (n=38) Atenolol (n=38) p
S wave, kW m−2 s−2 735 (586, 1049) 612 (443, 885) 0.007
D wave, kW m−2 s−2 220 (183, 284) 164 (106, 225) 0.001
c−1 wave, kW m−2 s−2 122 (74, 168) 97 (76, 150) 0.4
Wave speed, ms−1 6.67 (5.70, 9.28) 6.61 (5.22, 8.40) 0.4

Medians (25th, 75th percentiles), * Wilcoxon’s signed rank test

Conclusions: In hypertensive patients nebivolol has a more favourable effect than atenolol on left ventricular wave generation without increasing wave reflection.

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This is an open access article distributed under the CC BY-NC license.

1.K Niki et al., Heart Vessels, Vol. 17, 2002, pp. 12-21.
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Journal
Artery Research
Volume-Issue
3 - 4
Pages
171 - 171
Publication Date
2009/12/03
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2009.10.047How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - C. Park
AU  - J. Sever
AU  - A.W. Khir
AU  - C.L. Chang
AU  - S. Thom
AU  - A.D. Hughes
AU  - N. Poulter
PY  - 2009
DA  - 2009/12/03
TI  - P4.06 DIFFERENTIAL EFFECTS OF NEBIVOLOL AND ATENOLOL ON CAROTID ARTERIAL WAVE INTENSITY
JO  - Artery Research
SP  - 171
EP  - 171
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.047
DO  - 10.1016/j.artres.2009.10.047
ID  - Park2009
ER  -