P3.08 NITROGLYCERIN EFFECT ON AORTAL AUGMENTATION AND CENTRAL AUGMENTATION INDEX
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- 10.1016/j.artres.2011.10.043How to use a DOI?
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Background: Nitroglycerin (NG) reduces the systolic blood pressure, pulse pressure and augmentation index. The aim of our study was to evaluate the effect of NG on aortal augmentation (AA) and central augmentation index (CAI) in patients with different significance of the angiographically proved coronary artery disease (CAD).
Methods. The group of 66 patients referred for scheduled coronary angiography at Paul Stradins Clinical University Hospital Latvian Centre of Cardiology was analyzed. The mean age of patients was 62.8±11.9 years, 48.5% of them were male. The data about case history, cardiovascular risk factors, previous and concomitant therapy were collected. The applanation tonometry with Sphygmocor device, including radial pulse wave analysis (PWA), carotid PWA, carotid-femoral PWV before and after NG, was done. Coronary angiography was done for determination of presence and degree of coronary artery stenoses (CAS).
Results. Aortal augmentation and central augmentation index before and after nitroglycerin are seen in the Table 1.
| PWA | No CAS | CAS<50% | CAS 50–70% | CAS>70% | p value |
|---|---|---|---|---|---|
| AA before NG, mmHg | 12.7±10.9 | 17.4±7.2 | 15.3±6.4 | 22.0±9.9 | 0.012 |
| AA after NG, mmHg | 4.3±6.4 | 2.3±8.1 | 2.6±4.7 | 11.5±9.9 | 0.003 |
| CAI before NG, % | 25.2±16.3 | 36.0±17.9 | 28.6±6.8 | 37.0±10.0 | 0.019 |
| CAI after NG, % | 9.8±15.3 | 6.3±19.9 | 4.3±9.7 | 21.0±15.3 | 0.014 |
| AA decrease after NG, % | 86.0±62.9 | 80.8±39.0 | 89.1±25.5 | 48.4±47.8 | 0.061 |
| CAI decrease after NG, % | 89.6±73.9 | 71.4±45.4 | 87.7±34.2 | 46.5±38.6 | 0.055 |
PWA before and after NG test and CAS.
Conclusions. There is a tendency of less decrease of the aortal augmentation and central augmentation index after the nitroglicerine test in patients with significant CAS. Additive prognostic value of nitroglicerine test should be further explored in future studies.
Cite this article
TY - JOUR AU - M. Berzina AU - A. Krallisa AU - G. Latkovskis AU - M. Zabunova AU - I. Mintale AU - A. Erglis PY - 2011 DA - 2011/11/29 TI - P3.08 NITROGLYCERIN EFFECT ON AORTAL AUGMENTATION AND CENTRAL AUGMENTATION INDEX JO - Artery Research SP - 158 EP - 158 VL - 5 IS - 4 SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2011.10.043 DO - 10.1016/j.artres.2011.10.043 ID - Berzina2011 ER -