P5.22 CAROTID AND AORTIC STIFFNESS IN PATIENTS WITH HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA
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- 10.1016/j.artres.2011.10.077How to use a DOI?
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Aim: The role of plasma cholesterol in impairing arterial function and elasticity remains not completely defined. We evaluated the arterial stiffness, measured locally in the common carotid artery with a high-precision echo-tracking, and aortic stiffness, measured with carotid-femoral pulse wave velocity (PWV) (the «gold-standard» measurement of arterial stiffness), in patients with never-treated heterozygous familial hypercholesterolemia (FH).
Subjects and methods: The study included 66 FH patients aged 10–66 years (38 (27–48) years) and 57 their first-degree relatives without FH aged 11–61 years (33 (23–42) years). Carotid-femoral PWV was determined by SphygmoCor (AtCor, Australia). The parameters of carotid stiffness β-index, Peterson elastic modulus (Ep) and local PWV were assessed at the common carotid artery 1cm before the bifurcation (Aloka Prosound Alpha7, Japan). Data are represented as median (25th-75th percentile).
Results: There were no differences in age, sex, high-density lipoprotein cholesterol (HDL-C), C-reactive protein (CRP), fibrinogen, lipoprotein(a) (Lp(a)), homocysteine, cases of hypertension. The FH patients had significantly elevated total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), body mass index (BMI), frequency of tendon xanthomas, and coronary artery disease (CAD).
FH patients had significantly higher β-index (6,3(4,8–8,2) vs. 5,2(4,2–6,4), p=0,005), Ep (78(53–111)kPa vs. 62(48–79)kPa, p=0,006), local PWV (5,4(4,5–6,4)m/c vs. 4,7(4,2–5,4)m/c, p=0,005), but the same values of carotid-femoral PWV (6,76(7,0–7,92)m/c vs. 6,48(6,16–7,12)m/c, p=0,138).
Conclusions: Compared with their relatives, never-treated FH patients had stiffer carotid arteries but no differences in aortic stiffness.
This stidy was supported by the Grant for Scientific Research (#8/3–280н-10 and #8/3–281н-10) from Moscow City Government.
Cite this article
TY - JOUR AU - A.I. Ershova AU - A.N. Meshkov AU - T.A. Rozhkova AU - A.N. Rogoza AU - T.V. Balakhonova AU - S.A. Boytsov PY - 2011 DA - 2011/11/29 TI - P5.22 CAROTID AND AORTIC STIFFNESS IN PATIENTS WITH HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA JO - Artery Research SP - 169 EP - 169 VL - 5 IS - 4 SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2011.10.077 DO - 10.1016/j.artres.2011.10.077 ID - Ershova2011 ER -