Artery Research

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Volume 5, Issue 4, December 2011, Pages 187 - 187

P9.06 CORRELATES OF AUGMENTATION INDEX IN PATIENTS WITH NEVER TREATED UNCOMPLICATED NON-DIABETIC PATIENTS WITH ESSENTIAL HYPERTENSION

Authors
A. Berbari, S. Mallat, N. Daouk
American University of Beirut Medical Center, Beirut, Lebanon
Available Online 29 November 2011.
DOI
10.1016/j.artres.2011.10.140How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Objective: Assessment of the association between augmentation index (AI75) and hemodynamic factors and target organ damage in 98 patients with:

  1. 1)

    prehypertension (N=56, BP=120–139 / 80–89 mmHg)- GI

  2. 2)

    grade 1 hypertension (N=42, BP=140–160 / 90–100mmHg)- GII

Methods: Evaluated parameters: biochemical profile, sphygmocardiography (Augmentation Index-AI75 and central BP), echocardiography (Left Ventricular Mass/Height2.7- LVM/Ht2.7) and renal functional indices (Creatinine Clearance-Ccr and Urinary Albumin Excretion-UAE).

Results: (table)

GI GII
Age (Years) 45.5 ± 2 67.5 ± 1.9*
BMI (kg/m2) 27.9 ± 0.6 27.7 ± 0.6
SBPb (mmHg) 122 ± 1.9 143 ± 3.2*
DBPb (mmHg) 81 ± 1.4 78.5 ± 2.1
SBPc (mmHg) 114 ± 1.6 134 ± 3*
DBPc (mmHg) 82 ± 1.5 79 ± 2.2
PPb (mmHg) 41 ± 1.4 65 ± 3.1*
PPc (mmHg) 32 ± 0.8 55 ± 2.7*
LVM/Ht2.7 (g/m2.7) 60 ± 2 76 ± 4.9*
AI75 (%) 10.2 ± 5.6 39 ± 1*
Ccr (ml/min) 109.2 ± 5.6 71.9 ± 5.1*
UAE (mg/24hrs) 32 ± 8.2 56 ± 24.6
*

p< 0.05, SBP=systolic blood pressure, DBP=diastolic blood pressure, b=brachial, c=central, PP=pulse pressure, BMI=Body Mass Index

In middle age and elderly hypertensive subjects, increased AI75 is:

1) associated with increased central/brachial SBP and PP, increased LVM/Ht2.7, reduced Ccr and high UAE 2) independent of changes in biochemical profile.

Conclusion: Increased AI75 in never treated uncomplicated essential hypertension is: 1) associated with target organ damage; 2) probably a cardiovascular risk factor; 3) a sign of vascular disease which should be included in the evaluation of hypertensive patients.

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Journal
Artery Research
Volume-Issue
5 - 4
Pages
187 - 187
Publication Date
2011/11/29
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2011.10.140How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - A. Berbari
AU  - S. Mallat
AU  - N. Daouk
PY  - 2011
DA  - 2011/11/29
TI  - P9.06 CORRELATES OF AUGMENTATION INDEX IN PATIENTS WITH NEVER TREATED UNCOMPLICATED NON-DIABETIC PATIENTS WITH ESSENTIAL HYPERTENSION
JO  - Artery Research
SP  - 187
EP  - 187
VL  - 5
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2011.10.140
DO  - 10.1016/j.artres.2011.10.140
ID  - Berbari2011
ER  -