P2.06 LEVELS OF NT-PROBNP ARE ASSOCIATED WITH ARTERIAL STIFFNESS IN PATIENTS WITH RHEUMATOID ARTHRITIS
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- 10.1016/j.artres.2008.08.372How to use a DOI?
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Background: We wished to investigate the association between arterial stiffness and NT-proBNP, a biomarker released in response to atrial and ventricular stretch (RA).
Methods: AI and PWV were measured using the Sphygmocor apparatus (Atcor) in 108 patients, 92 patients had acceptable AI, 95 patients acceptable PWV readings. The patients are included in the Euridiss register, an ongoing longitudinal study of Rheumatoid Arthritis (RA) disease activity. Cardiovascular end-points were assessed at the 2007 follow-up. AI and PWV were corrected for age, sex , MAP and heart rate and were dependent variables in separate models. AI was also corrected for height. Multivariate linear regression analysis with NT-proBNP as a continuous variable and ANOVA analysis with quartiles of NT-proBNP were performed.
Results: NT-proBNP was associated to PWV in the multivariate linear regression ß(CI) 0.024 (0.002–0.046) p=0.03. R2 adjusted 0.57 R2 change 0.02 p=0.03. The ANOVA analysis is shown below. NT-proBNP was not associated to AI ß(CI) 0.072 (−0.026–0.170) p=0.15.
Conclusion: NT-proBNP is associated to levels of PWV in patients with RA.
Cite this article
TY - JOUR AU - S.A. Provan AU - K. Angel AU - P. Mowinckel AU - S. Agewall AU - D. Atar AU - T.K. Kvien PY - 2008 DA - 2008/09/15 TI - P2.06 LEVELS OF NT-PROBNP ARE ASSOCIATED WITH ARTERIAL STIFFNESS IN PATIENTS WITH RHEUMATOID ARTHRITIS JO - Artery Research SP - 107 EP - 108 VL - 2 IS - 3 SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2008.08.372 DO - 10.1016/j.artres.2008.08.372 ID - Provan2008 ER -