P2.51 PRECLINICAL ATHEROSCLEROTIC DISEASE AND METABOLIC SYNDROME: A PREDIABETES STAGE?
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- 10.1016/j.artres.2008.08.417How to use a DOI?
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Aim: In ESH/ESC 07 Guidelines, Metabolic Syndrome (MS) and subclinical vascular disease (VD) are stressed as important markers of high risk in asymptomatic subjects. We compared the severity of VD by ultrasonography in patients (p.) with MS and Diabetes Mellitus (DM) and control (C) p. to analyze the relationship between the metabolic condition and the severity of VD.
Methods: We did in the same procedure 1) CIMT 2) Plaques characterization, 3) PWV and 4) FMD with a strict quality control. We set a score (VS) from 0 to 5 according to the severity of the VD. The CV Risk using Framingham score (FS) was also obtained from medical records.
Results: We performed a cross sectional, observational study on 292 matched p., 125 C without dyslipemia or overweight, 138 with MS (according ATP III criteria) and 29 with DM..
| Parameter | C (n= 125) | MS (n= 138) | DBT (n= 29) | p |
|---|---|---|---|---|
| Age | 54 ± 12 | 54 ± 11 | 51 ± 10 | NS |
| Sex (% males) | 70 | 64 | 52 | NS |
| SBP (mmHg) | 141 ± 18 | 141 ± 16 | 142 ± 10 | NS |
| DBP (mmHg) | 85 ± 11 | 86 ± 9 | 87 ± 10 | NS |
| HR (bpm) | 69 ± 9 | 71 ± 10 | 74 ± 10 | NS |
| % abnormal IMT | 19 | 33 | 41 | .012 |
| % Plaques | 22 | 54 | 55 | < 001 |
| %Abnormal FMD | 33 | 39 | 45 | NS |
| %Abnormal PWV | 30 | 38 | 65 | .002 |
| FS (mean) | 10 ± 8 | 10 ± 6 | 25 ± 12 | < 001 |
| VS (mean) | 2,1 ± 1,4 | 2,5 ± 1,4 | 3,0 ± 1,7 | .004 |
Conclusions: 1- In a selected population of matched p. according to age, sex and BP, there seems to be an increase in the degree of VD when MS is present. 2- The pattern of VD in MS p. was close to that in DM p. consistent with the described increase in CV risk in MS.3-A VS may be useful in the clinical practice.
Cite this article
TY - JOUR AU - P. Forcada AU - C. Kotliar AU - S. Obregon AU - G. Millet AU - J. Guerrieri AU - O. Montana AU - C. Schulte AU - D. Turri PY - 2008 DA - 2008/09/15 TI - P2.51 PRECLINICAL ATHEROSCLEROTIC DISEASE AND METABOLIC SYNDROME: A PREDIABETES STAGE? JO - Artery Research SP - 118 EP - 119 VL - 2 IS - 3 SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2008.08.417 DO - 10.1016/j.artres.2008.08.417 ID - Forcada2008 ER -