1.3 THE ASSOCIATION BETWEEN CIRCULATING UNDECARBOXYLATED MATRIX GLA PROTEIN AND ARTERIAL STIFFNESS IN GENERAL POPULATION
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- 10.1016/j.artres.2014.09.052How to use a DOI?
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Background: Matrix Gla protein (MGP), a natural calcification inhibitor, strongly correlated with the extent of coronary calcification. Vitamin K is the essential cofactor for activation of MGP. We aimed to establish whether there is also any association between dephosphorylated-uncarboxyled isoform of MGP (dp-ucMGP) and pulse wave velocity (PWV) in random sample of general population.
Methods: 1003 general population subjects (a subsample of postMONICA study undertaken in 2008) were analyzed in cross-sectional study. Aortic and peripheral PWV were quantified using Sphygmocor device, dp-ucMGP concentrations form frozen samples by ELISA methods using inaKtif pre-commercial kist developed by VitaK (Maastricht, Netherlands)
Results: Aortic, but not peripheral PWV significantly (with p<0.0001) increased among dp-ucMGP quartile. Using multiple logistic regression, subjects in top quartile of dp-ucMGP (≥ 675 pmol/L) shows about two-times higher risk of having high aPWV (≥ 9.3 m/sec) or an absolute increase of PWV by 1 m/sec, even if adjusted for potential covariates (age, history of vascular disease, obesity, raised blood pressure and overt diabetes also entered significantly the regression model).
Conclusion: Increased dp-ucMGP as circulating biomarker of vitamin K status and vascular calcification independently predicts high central-type, large artery stiffness. In contrast, peripheral muscular-type arteries remain uninfluenced.
(supported by IGA Ministry of Health, grant nos 12102 and 13186)
Cite this article
TY - JOUR AU - O. Mayer AU - J. Seidlerová AU - J. Filipovský AU - C. Vermeer PY - 2014 DA - 2014/11/04 TI - 1.3 THE ASSOCIATION BETWEEN CIRCULATING UNDECARBOXYLATED MATRIX GLA PROTEIN AND ARTERIAL STIFFNESS IN GENERAL POPULATION JO - Artery Research SP - 122 EP - 122 VL - 8 IS - 4 SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2014.09.052 DO - 10.1016/j.artres.2014.09.052 ID - Mayer2014 ER -