Artery Research

Volume 6, Issue 4, December 2012, Pages 142 - 142

1.5 BLOOD PRESSURE-INDEPENDENT ASSOCIATION BETWEEN AORTIC CHARACTERISTIC IMPEDANCE AND LEFT VENTRICULAR MASS IN HYPERTENSION

Authors
G. Pucci1, F. Battista1, L. Settimi1, B. Hametner2, S. Wassertheurer2, G. Schillaci1
1University of Perugia at Terni, Terni, Italy
2Austrian Institute of Technology, Vienna, Austria
Available Online 17 November 2012.
DOI
10.1016/j.artres.2012.09.011How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Background: It is uncertain whether pressure/flow ratio in the proximal aorta, namely aortic characteristic impedance (Zc), is related to left ventricular (LV) mass independently of blood pressure (BP) level.

Methods: 435 never-treated subjects with uncomplicated essential hypertension free from overt cardiovascular disease (men 62%, age 48±11 years, BP 148/92±16/10 mmHg) underwent M-mode echocardiography and 24-hour BP monitoring. Aortic waveform was obtained from tonometric radial waveform with a validated generalized transfer function (SphygmoCor). Aortic Zc and forward (Pf) and backward (Pb) wave amplitudes were calculated from central waveform using an aortic blood flow model based on higher-order Windkessel theory (ArcSolver), [Weber T et al, Hypertension EPub May 14, 2012].

Results: Patients with LV hypertrophy (LV mass >51 g/m2.7) had a higher brachial systolic BP (SBP 153±18 vs 146±15 mmHg, p<0.001), central systolic BP (142±18 vs 133±16 mmHg, p<0.001), aortic Zc (0.235±0.08 vs 0.211±0.06 AU, p<0.001), Pf (31.7±9 vs 28.6±7 mmHg, p<0.001), and Pb (19.8±7 vs 18.1±5 mmHg, p=0.02), while reflection magnitude (Pb/Pf) did not differ (0.62±0.10 vs 0.63±0.10, p>0.3). After controlling for age, sex, and mean arterial pressure as a measure of distending pressure, LV mass index maintained an independent association with Zc (partial r=0.14, p=0.002), while the association of either Pb or Pf with LV mass became no longer significant. In a multiple linear regression model, Zc independently predicted LV mass index (β=0.116, p=0.005) along with age, mean arterial pressure, and body mass index.

Conclusion: Aortic characteristic impedance has a significant, pressure-independent relationship with LV mass in human hypertension.

Journal
Artery Research
Volume-Issue
6 - 4
Pages
142 - 142
Publication Date
2012/11/17
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2012.09.011How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - G. Pucci
AU  - F. Battista
AU  - L. Settimi
AU  - B. Hametner
AU  - S. Wassertheurer
AU  - G. Schillaci
PY  - 2012
DA  - 2012/11/17
TI  - 1.5 BLOOD PRESSURE-INDEPENDENT ASSOCIATION BETWEEN AORTIC CHARACTERISTIC IMPEDANCE AND LEFT VENTRICULAR MASS IN HYPERTENSION
JO  - Artery Research
SP  - 142
EP  - 142
VL  - 6
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2012.09.011
DO  - 10.1016/j.artres.2012.09.011
ID  - Pucci2012
ER  -