Artery Research

Volume 6, Issue 4, December 2012, Pages 152 - 152

P1.06 IS IMPAIRED FASTING GLUCOSE ASSOCIATED WITH SUBCLINICAL ARTERIAL DISEASE? THE STRONG HEART STUDY

Authors
M.J. Roman1, R.B. Devereux1, I. Hriljac1, E.T. Lee4, L.G. Best3, B.V. Howard2
1Weill Cornell Medical College, New York, NY, United States
2Medstar Research Institute, Washington, DC, United States
3Missouri Breaks Industries Research, Timber Lake, SD, United States
4University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States
Available Online 17 November 2012.
DOI
10.1016/j.artres.2012.09.043How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Background: Vascular disease is a leading cause of morbidity and mortality in diabetes mellitus (DM). It is uncertain whether pre-diabetes (impaired fasting glucose [IFG]) increases risk for subclinical vascular disease.

Methods: Cardiovascular disease (CVD) risk factors and carotid artery structure (wall thickness [IMT] and vascular mass) and presence and extent of atherosclerosis were compared in 2461 Strong Heart Study participants free of prevalent CVD: 1038 with normal fasting glucose (NFG), 254 with IFG (110–125 mg/dl), and 1169 with DM.

Results: Participants with IFG were more obese and had lower HDL cholesterol than those with NFG but were comparable in other CVD risk factors. Participants with DM were more likely to be female, hypertensive, non- smoking, and to have higher triglycerides than the other two groups. Following adjustment for differences in CVD risk factors, DM had greater carotid IMT (0.75 mm), mass (16.38 mm2) and presence (69.1%) and extent (log transformed plaque score: 0.78) of atherosclerosis compared to NFG and IFG. NFG and IFG had comparable adjusted IMT (0.73 vs. 0.73 mm), arterial mass (15.51 vs. 15.67 mm2), plaque (58.8 vs. 58.5 %) and plaque score (0.64 vs. 066).

Conclusions: Other than elevated fasting glucose, the distinguishing features of IFG are obesity and reduced HDL cholesterol (comparable to DM). Greater degrees of arterial hypertrophy and atherosclerosis are seen in DM but not IFG. These findings have implications for public health efforts to identify individuals with IFG and intervene to limit progression to the vascular disease associated with DM.

Journal
Artery Research
Volume-Issue
6 - 4
Pages
152 - 152
Publication Date
2012/11/17
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2012.09.043How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - M.J. Roman
AU  - R.B. Devereux
AU  - I. Hriljac
AU  - E.T. Lee
AU  - L.G. Best
AU  - B.V. Howard
PY  - 2012
DA  - 2012/11/17
TI  - P1.06 IS IMPAIRED FASTING GLUCOSE ASSOCIATED WITH SUBCLINICAL ARTERIAL DISEASE? THE STRONG HEART STUDY
JO  - Artery Research
SP  - 152
EP  - 152
VL  - 6
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2012.09.043
DO  - 10.1016/j.artres.2012.09.043
ID  - Roman2012
ER  -