Artery Research

Volume 6, Issue 4, December 2012, Pages 157 - 157

P1.23 CENTRAL AORTIC PRESSURE AND ARTERIAL STIFFNESS PATTERNS ACCORDING TO DRUGS AND GENDER IN HYPERTENSIVE PATIENTS

Authors
P. Forcada, D. Olano, S. Obregon, S. Gonzalez, C. Castellaro, J. Chiabaut, F. Inserra, C. Kotliar
Hospital Universitario Austral, Pilar Buenos Aires, Argentina
Available Online 17 November 2012.
DOI
10.1016/j.artres.2012.09.060How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Background: Previously we described differences in central pressures and arterial stiffening according to gender and age, which are related to increased risk in elder women (W) and different responses to treatment.

Objectives: To study different arterial stiffness patterns in essential hypertensives (H) according to gender and different antihypertensives.

Methods: We included 564 H from JAN2007 to DIC2010. Inclusion criteria: age >40 and <70,at least 2 CV risk factors and 6 mo.under stable monotherapy with atenolol (ATEN)n:114, amlodipine (AML)n:113, enalapril: (ENL)n:195 or losartan (LOS)n:142. A Control group (C) was also included (131p). All with a rate males/women (M/W) 2/1. Evaluations: BP, cIMT, Plaques, cf PWV, Endothelial Function (EF), Central/Peripheral Pulse Pressure (PPc/PPp) and Augmentation Indexes (Aix c /Aix p).(Hemodyn 4/Arteriograph ®). Statistics: t test, ANOVA, Dunnet p <0,05.

Results: (only signif.) Peripheral BP, PP and PWV were higher in H than C. PPc and Aix c were higher in H than in C and in W than in M in every group. Aix p in H, were higher and positive in W and lower and negative in M. PWV was higher in M than W only in H. (table attached)

Conclusion: According to PP and Aix, two patterns: In M a“central stiffness pattern” with lower PPc than PPp, negative Aix p and higher PWV.

In W a“peripheral stiffness pattern” with higher PPc, positive Aix p and lower PWV. This last pattern could be related with the increased risk in elder W and was not corrected by treatment.

Parameters CONTROLS ATEN AML ENL LOS
GENDER M (89) F (42) M (75) F (39) M (66) F 47) M (135) F (60) M (95) F (47)
AGE 49 ± 7 47,5± 7 56 ± 8 56 ± 8 55 ± 8 54 ± 9 55 ± 8 56 ± 8 57 ± 8 55 ± 7
SBP mmHg 127 ± 14 118,5 ± 14 131 ± 14 131 ± 12 136 ± 12 133 ± 11 135 ± 13 132 ± 12 131 ± 12 133 ± 12
DBP mmHg 80 ± 10 75 ± 9 83 ± 9 81 ± 8 84 ± 8 80 ± 10 84 ± 7,5 81 ± 8 83 ± 7,5 82 ± 8
HR lpm 63 ± 12 71 ± 11 61 ± 11 62 ± 7 66 ± 10 68 ± 12 67 ± 15 69 ± 11 66 ± 11 67 ± 12
PP c mmHg 37 ± 8 43 ± 9 48 ± 11 56 ± 10 48 ± 14 51 ± 12 47 ± 12 52 ± 11 46 ± 14 55 ± 9
PP p mmHg 47 ± 8 43 ± 10 48 ± 10 50 ± 9 51,5 ± 9 52,5 ± 15 51 ± 10 51 ± 10 48 ± 10 51 ± 7,5
Aix c % 19 ± 9,5 31 ± 12 32 ± 11,5 43 ± 8 30 ± 12 41 ± 9 28 ± 14 38 ± 11 27 ± 11 41 ± 11
Aix p % −30 ± 26,5 −7 ± 31 4 ± 3 24 ± 18 −5 ± 28 19 ± 20 −10 ± 36 18 ± 47 −13 ± 26 16,5 ± 27,5
PWV m/s 9 ± 2 9 ± 2 12 ± 9,5 10 ± 3 12 ± 2 10 ± 2 12 ± 2 10 ± 2 11 ± 2 10 ± 2

Ref: SBP: Systolic Blood Pressure DBP: Diastolic Blood pressure HR: Heart Rate PPc: Central Pulse Pressure PPp: Peripheral Pulse Pressure Aix c: Central Augmentation Index Aix p: Peripheral Augmentation Index PWV: Pulse Wave Velocity.

Journal
Artery Research
Volume-Issue
6 - 4
Pages
157 - 157
Publication Date
2012/11/17
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2012.09.060How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - P. Forcada
AU  - D. Olano
AU  - S. Obregon
AU  - S. Gonzalez
AU  - C. Castellaro
AU  - J. Chiabaut
AU  - F. Inserra
AU  - C. Kotliar
PY  - 2012
DA  - 2012/11/17
TI  - P1.23 CENTRAL AORTIC PRESSURE AND ARTERIAL STIFFNESS PATTERNS ACCORDING TO DRUGS AND GENDER IN HYPERTENSIVE PATIENTS
JO  - Artery Research
SP  - 157
EP  - 157
VL  - 6
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2012.09.060
DO  - 10.1016/j.artres.2012.09.060
ID  - Forcada2012
ER  -