Artery Research

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Volume 6, Issue 4, December 2012, Pages 154 - 154

P1.12 ETHNIC DIFFERENCES IN LEFT VENTRICLE MYOCARDIAL OXYGEN DEMAND

Authors
C.M. Park, K. March, T. Tillin, N. Chaturvedi, A.D. Hughes
ICCH, C. ImperialL. ollegeondon, London, K. United kingdom
Available Online 17 November 2012.
DOI
10.1016/j.artres.2012.09.049How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Background: There are marked inter-ethnic differences in coronary heart disease (CHD). Indian Asians (IA) have 50% greater and African Caribbeans (AC) 50% less CHD than white Europeans (E) in the UK. Reasons for this are unclear. We compared ventricular structure and function, specifically myocardial oxygen demand, by ethnicity.

Methods and Results: 3D echocardiography (Philips iE33) and radial applanation tonometry (SphygmoCor) were performed on 800 men and women (age 55–85) from the Southall And Brent REvisited (SABRE) tri-ethnic population-based cohort. Left ventricular mass index (LVMI) was measured, and 3D LV remodelling index (LVRI) was calculated as LV mass/LV end diastolic volume. 3D cardiac output (CO) and total peripheral resistance (TPR) were calculated and 3D LV end systolic active fibre stress (AFS) and wasted effort (∆Ew) were derived as markers of myocardial oxygen demand.

LVMI did not differ between E and AC but was significantly lower in IA. LVRI was greatest in AC and smallest in IA. IA and AC had lower CO and higher TPR compared to E. AFS and ∆Ew were significantly higher in IA. These ethnic differences persisted after multivariate adjustment for age, sex, heart rate, systolic blood pressure, fasting blood glucose and insulin concentrations and medication.

Conclusions: AC have comparable LVMI and myocardial oxygen demand to E. In contrast IA generate significantly more AFS and ∆Ew despite having less myocardial muscle. This implies that IA have increased myocardial oxygen demand which may increase susceptibility to myocardial ischemia, and which could contribute to their excess risk of CHD.

European Indian Asian African Caribbean ANOVA P value
n 372 294 134
LVMI (g/m 2.7) 29.7±0.3 28.2±0.4* 29.6±0.6 0.02
LVRI 1.52±0.02 1.48±0.02 1.60±0.03* 0.005
CO (L) 3.5±0.04 3.1±0.05** 3.01±0.07** <0.0001
TPR(mmHg/L) 29.5±0.5 33.4±0.5** 36.1±0.8** <0.0001
AFS(kPa) 22.6±0.5 24.3±0.6* 22.2±0.8 0.04
Ew(dyne/s/cm2 102) 45±1 52±2* 49±3 <0.0001
Table 1

Data are mean±SE by ethnicity (adjusted for age). * = p<0.05 ** = p<0.01 compared with Europeans by post hoc test following ANOVA.

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Journal
Artery Research
Volume-Issue
6 - 4
Pages
154 - 154
Publication Date
2012/11/17
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2012.09.049How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - C.M. Park
AU  - K. March
AU  - T. Tillin
AU  - N. Chaturvedi
AU  - A.D. Hughes
PY  - 2012
DA  - 2012/11/17
TI  - P1.12 ETHNIC DIFFERENCES IN LEFT VENTRICLE MYOCARDIAL OXYGEN DEMAND
JO  - Artery Research
SP  - 154
EP  - 154
VL  - 6
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2012.09.049
DO  - 10.1016/j.artres.2012.09.049
ID  - Park2012
ER  -