Artery Research

Volume 6, Issue 4, December 2012, Pages 160 - 160

P1.31 INCREASED VASCULAR AGE IN TREATED HYPERTENSIVE PATIENTS WITH ELEVATED AUGMENTATION INDEX

Authors
M.F. Neves1, A.R. Cunha1, M.A. Casanova1, M. Trindade1, J. d’El-Rei2, F. Medeiros2, W. Oigman1
1State University of Rio de Janeiro, Rio de Janeiro, Brazil
2Federal University of State of Rio de Janeiro, Rio de Janeiro, Brazil
Available Online 17 November 2012.
DOI
10.1016/j.artres.2012.09.068How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Objective: To identify clinical and vascular parameters associated with increased augmentation index (Aix) in treated hypertensive patients.

Methods: Hypertensive patients, aged 30–74 years, were evaluated using high-resolution ultrasonography for brachial flow-mediated dilation (FMD), EndoPat 2000 for peripheral arterial tonometry and Sphygmocor to obtain central hemodynamic parameters. Vascular age was calculated after estimating Framingham risk score. Patients (n=177) were distributed into three equal groups (n=59 each) according to Aix values: 1st tertil (T1) Aix<28%, 2nd tertil (T2) Aix 28–37%, 3rd tertil (T3) Aix>37%.

Results: The mean age was not different among the groups (55±11 vs 57±10 vs 58±8 years). T3 group presented significant increase in brachial SBP (139±17 vs 145±17 vs 151±22 mmHg, p=0.006), aortic SBP (126±16 vs 138±17 vs 148±24 mmHg, p<0.001), and aortic pulse pressure (41±10 vs 49±14 vs 60±21 mmHg, p<0.001). Aix obtained by EndoPat (14±13 vs 30±19 vs 30±18 %, p<0.001) and vascular age (71±16 vs 77±13 vs 78±12 years, p=0.019) were significantly greater in T2 and T3 comparing to T1. There was no significant differences in endothelial function evaluated by brachial FMD (7.5±5.1 vs 8.9±5.5 vs 9.2±6.7 %) and through reactive hyperemia index by EndoPat (1.9±0.5 vs 2.2±0.7 vs 1.9±0.4 units). Aix was not correlated to age, but was significantly correlated to vascular age (r=0.22, p=0.005), brachial SBP (r=0.21, p=0.006) and to aortic SBP (r=0.40, p<0.001).

Conclusion: In this population of treated hypertension, increased vascular stiffness characterized by an elevated augmentation index was associated to increased vascular age but not with worse endothelial function.

Journal
Artery Research
Volume-Issue
6 - 4
Pages
160 - 160
Publication Date
2012/11/17
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2012.09.068How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - M.F. Neves
AU  - A.R. Cunha
AU  - M.A. Casanova
AU  - M. Trindade
AU  - J. d’El-Rei
AU  - F. Medeiros
AU  - W. Oigman
PY  - 2012
DA  - 2012/11/17
TI  - P1.31 INCREASED VASCULAR AGE IN TREATED HYPERTENSIVE PATIENTS WITH ELEVATED AUGMENTATION INDEX
JO  - Artery Research
SP  - 160
EP  - 160
VL  - 6
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2012.09.068
DO  - 10.1016/j.artres.2012.09.068
ID  - Neves2012
ER  -