Artery Research

Volume 6, Issue 4, December 2012, Pages 162 - 163

P1.43 INTERACTION OF HYPERALBUMINURIA, ARTHEROSCLEROTIC PLAQUES AND ELEVATED PULSE WAVE VELOCITY WITH AGE AND RISK CATEGORY IN APPARENTLY HEALTHY SUBJECTS

Authors
S.V. Greve1, M. Blicher2, A. Blyme3, T. Sehestedt4, T.W. Hansen5, S. Rasmussen6, J. Vishram7, H. Ibsen8, C. Torp-Pedersen9, M.H. Olsen10
1Cardiovascular and Metabolic Preventive Clinic, Department of Endocrinology, Odense University Hospital, Odense, Denmark
2Cardiovascular and Metabolic Preventive Clinic, Department of Endocrinology, Odense University Hospital, Odense, Denmark
3Cardiovascular Research Unit, Department of Internal Medicine, Glostrup University Hospital, Glostrup, Denmark
4Department of Cardiology, Herlev University Hospital, Herlev, Denmark
5Department of Clinical Physiology and Nuclear Medicine, Rigshospitalet, Copenhagen, Denmark
6Department of Diagnostic Imaging, Gentofte University Hospital, Gentofte, Denmark
7Research Center for Prevention and Health, Copenhagen, Denmark
8Department of Internal Medicine, Holbæk Hospital, Holbæk, Denmark
9Department of Cardiology, Gentofte University Hospital, Gentofte, Denmark
10Cardiovascular and Metabolic Preventive Clinic, Department of Endocrinology, Odense University Hospital, Odense, Denmark
Available Online 17 November 2012.
DOI
10.1016/j.artres.2012.09.080How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Subclinical vascular damage (SVD) predicts cardiovascular events independently of traditional risk factors in apparently healthy subjects. But information on coexistence and additive prognostic importance in different age and groups are lacking. In 2082 apparently healthy subjects aged 41, 51, 61 and 71 years we estimated cardiovascular risk using SCORE, performed ultrasound of the carotid arteries and measured urine albumin/creatinine ratio (UACR) and pulse wave velocity (PWV) in 1993. The composite endpoint (CEP) of cardiovascular death, non-fatal myocardial infarction and stroke, and hospitalization for ischemic heart disease was recorded until 2006. Between the four age groups and the four SCORE risk groups, the prevalence of hyperalbuminuria (above 90 percentile), atherosclerotic plaques and elevated PWV increased. The prevalence of subjects with one or more SVD increased between the four age groups as well as the four risk groups. Increasing numbers of markers for SVD (0, 1, 2 or 3) was associated with higher incidence of CEP in the three youngest age groups (41+51 years: 4.7, 9.4, 20.8, 50%; 61 years: 7.7, 15.3, 25.9, 35.7%, both P<0.001; 71 years: 21.2, 21.5, 27.9, 43.3%, P=0.08) and in patients with SCORE<10% (SCORE<5%: 4.6, 9.2, 20.6, 60%, P<0.001; 5≤SCORE<10%: 9.8, 18.4, 20.8, 36.8%, P<0.05%; SCORE ≥10%: 25.0, 23.5, 35.4, 42.3%, NS). Concluding that the advantage of combined markers for SVD is doubtful in subjects aged 41 years or SCORE<1% due to low prevalence as well as in subjects aged 71 years or SCORE≥10% due very high prevalence and low additive predictive value.

Journal
Artery Research
Volume-Issue
6 - 4
Pages
162 - 163
Publication Date
2012/11/17
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2012.09.080How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - S.V. Greve
AU  - M. Blicher
AU  - A. Blyme
AU  - T. Sehestedt
AU  - T.W. Hansen
AU  - S. Rasmussen
AU  - J. Vishram
AU  - H. Ibsen
AU  - C. Torp-Pedersen
AU  - M.H. Olsen
PY  - 2012
DA  - 2012/11/17
TI  - P1.43 INTERACTION OF HYPERALBUMINURIA, ARTHEROSCLEROTIC PLAQUES AND ELEVATED PULSE WAVE VELOCITY WITH AGE AND RISK CATEGORY IN APPARENTLY HEALTHY SUBJECTS
JO  - Artery Research
SP  - 162
EP  - 163
VL  - 6
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2012.09.080
DO  - 10.1016/j.artres.2012.09.080
ID  - Greve2012
ER  -