Artery Research

Volume 6, Issue 4, December 2012, Pages 175 - 175

P2.40 TENSILE MEASUREMENTS ON VERY SMALL BLOOD VESSELS AND VASCULAR GRAFTS

Authors
M.S. Stoiber1, 4, C.G. Grasl1, 4, K.K. Kessler3, B.M. Messner3, D.B. Bernhard3, V.G. Gschlad1, 2, H.S. Schima1, 2, 4
1Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria
2Deptartment of Cardiac Surgery, Medical University of Vienna, Vienna, Austria
3Cardiac Surgery Research Laboratories, Department of Surgery, Medical University of Vienna, Vienna, Austria
4Ludwig-Boltzmann-Cluster for Cardiovascular Research, Vienna, Austria
Available Online 17 November 2012.
DOI
10.1016/j.artres.2012.09.120How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Aims: Biomechanical evaluation of small blood vessels and vascular grafts is an important task. In this work a method is presented for testing mechanical behaviour of very small tubular structures with less than 1mm diameter.

Methods: For the tensile measurements a BOSE ElectroForce system (Bose Corp. MN, USA) with a controllable linear motor for static and dynamic measurements was used. To measure very small ring-shaped specimens the system was modified with a cantilever and a special designed probe fixation.

Firstly, tensile behaviour on thoracic mice aortae after 19 weeks high-fat-diet (group 1) and a control group (group 2) were analyzed. Secondly, on electrospun vascular grafts repeated loading-unloading measurements were performed to obtain the dynamic behaviour in the physiological range.

Results: The modified system allowed measurements on very small specimen (0.7mm inner diameter in case of the mice aortae) and the use of very sensitive load cells of 10N and up to 0.5N.

For the mice aortae significant higher maximum tear forces in group 1 with 0.41 +/− 0.12N, than in group 2 with 0.34 +/− 0.10N were measured. Diverse tear forces and braking strains at different zones of the aorta could be observed. For the vascular grafts hysteresis curves could be recorded with peak-to-valley forces of 0.03 to 0.08N, corresponding to 80 and 120mmHg.

Conclusion: The established method enables a reproducible and sensible measurement of static and dynamic mechanical properties in small ring-shaped specimen of arteries and vascular prostheses.

Journal
Artery Research
Volume-Issue
6 - 4
Pages
175 - 175
Publication Date
2012/11/17
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2012.09.120How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - M.S. Stoiber
AU  - C.G. Grasl
AU  - K.K. Kessler
AU  - B.M. Messner
AU  - D.B. Bernhard
AU  - V.G. Gschlad
AU  - H.S. Schima
PY  - 2012
DA  - 2012/11/17
TI  - P2.40 TENSILE MEASUREMENTS ON VERY SMALL BLOOD VESSELS AND VASCULAR GRAFTS
JO  - Artery Research
SP  - 175
EP  - 175
VL  - 6
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2012.09.120
DO  - 10.1016/j.artres.2012.09.120
ID  - Stoiber2012
ER  -