According to Debasso et al., the popliteal artery depicts a muscular artery with wall properties similar to that of the central conduit arteries. Some literature show differences in arterial composition between popliteal arteries and other fellow peripheral muscular arteries and may comprise both central and peripheral properties. The objective was to investigate whether the popliteal artery resemble the carotid artery in structure and function in young and older Caucasian men. Forty one participants were divided in a young-, aged 20–30 years (n=21) and an older group aged 40–60 years (n=20). Cardiovascular and anthropometric measurements were executed which included blood pressure, carotid femoral PWV (Complior SP Acquisition system) as well as popliteal and carotid IMT (Vivid E9, GE). An inverse association (r=−0.78; p<0.001) between popliteal IMT and c-fPWV in young men were encountered after adjusted for age, BMI and smoking. Carotid IMT and popliteal IMT differed significantly (p<0.001) in both age groups. The mean CSWA of carotid and popliteal arteries also differed significantly when young and older men were compared. In the young men the mean CSWA of the carotid artery differed significantly from the popliteal CSWA (1.83 cm vs. 1.60 cm; p=0.013) but not in the older men. To conclude the popliteal and carotid arteries in young and older Caucasian men do not exhibit similar structural or functional properties.