Artery Research

Volume 6, Issue 4, December 2012, Pages 183 - 184

P4.03 ORAL LYCOPENE SUPPLEMENTATION IMPROVES ENDOTHELIAL FUNCTION IN PATIENTS WITH CARDIOVASCULAR DISEASE: A RANDOMISED CONTROLLED TRIAL

Authors
P.R. Gajendragadkar1, A. Hubsch1, K. Mäki-Petäjä1, M. Serg2, I.B. Wilkinson1, J. Cheriyan1
1Department of Clinical Pharmacology, University of Cambridge, Cambridge, United Kingdom
2Department of Cardiology, University of Tartu, Tartu, Estonia
Available Online 17 November 2012.
DOI
10.1016/j.artres.2012.09.151How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Introduction: Lycopene is a potent antioxidant and carotenoid in the ‘Mediterranean diet’. Plasma and adipose lycopene concentrations have previously been inversely correlated with cardiovascular disease (CVD) risk. We hypothesised that a standardised preparation of lycopene would improve endothelial function.

Methods: 36 healthy volunteers (HV) and 36 stable CVD patients on statins were randomised unequally (2:1) to either 7mg lycopene or placebo daily for 2 months (NCT01100385). Forearm blood flow responses to intra-arterial infusions of acetylcholine, (endothelium-dependent vasodilatation,EDV); sodium nitroprusside (endothelium-independent vasodilatation.EIDV); and NG-monomethyl-L-arginine (measuring basal nitric oxide,NO) were measured using venous plethysmography.

Results: At baseline, both groups were similar in age, BP and hs-CRP but the CVD group had a lower LDL (2.4 ±0.6 vs. 3.6 ±0.9mmol/L, P<0.001). The CVD group had impaired EDV to ACh compared with HV (30% lower; 95%CI: −45, −10, P=0.008). Lycopene improved EDV in CVD patients by 53% (95%CI: +9, +93, P=0.03 vs. placebo) independent of changes in EIDV or basal NO. Lycopene did not change EIDV, EDV or basal NO in HV. Home blood pressure, LDL, HDL and hs-CRP levels were unchanged in both groups. A post-hoc analysis demonstrated that lycopene treatment improved EDV in CVD patients towards HV levels at baseline (3% lower; 95% CI: −30, +30, P=0.85), suggesting normalization of vascular function.

Conclusion: Lycopene supplementation improves endothelial function in CVD patients but not HV, and may require further investigation in larger outcome studies.

Journal
Artery Research
Volume-Issue
6 - 4
Pages
183 - 184
Publication Date
2012/11/17
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2012.09.151How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - P.R. Gajendragadkar
AU  - A. Hubsch
AU  - K. Mäki-Petäjä
AU  - M. Serg
AU  - I.B. Wilkinson
AU  - J. Cheriyan
PY  - 2012
DA  - 2012/11/17
TI  - P4.03 ORAL LYCOPENE SUPPLEMENTATION IMPROVES ENDOTHELIAL FUNCTION IN PATIENTS WITH CARDIOVASCULAR DISEASE: A RANDOMISED CONTROLLED TRIAL
JO  - Artery Research
SP  - 183
EP  - 184
VL  - 6
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2012.09.151
DO  - 10.1016/j.artres.2012.09.151
ID  - Gajendragadkar2012
ER  -