Artery Research

Volume 6, Issue 4, December 2012, Pages 187 - 188

P4.16 INSULIN RESISTANCE IS ASSOCIATED WITH INCREASED LARGE ARTERY STIFFNESS IN NORMOTENSIVE HEALTHY ADULTS

Authors
J.E. Ochoa1, 3, M.M. Correa2, A.M. Valencia2, J.G. McEwen2, J.A. Gallo2, G. Bilo3, P. Salvi3, D. Aristizabal2, G. Parati1, 3
1Department of Clinical Medicine and Prevention, University of Milano-Bicocca, Milan, Italy
2Corporación para Investigaciones Biologicas, Clinical and Research Center, SICOR, Medellin, Colombia
3Department of Cardiology, S. Luca Hospital, Istituto Auxologico Italiano, Milan, Italy
Available Online 17 November 2012.
DOI
https://doi.org/10.1016/j.artres.2012.09.164How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Aim: At present there is limited evidence on the relationship between insulin resistance (IR) and measures of large artery stiffness (AS) and wave reflections in normotensive healthy adults. Aim of the present study was to explore this issue in 90 normotensive (Systolic(S) blood pressure(BP) 107.1±9.3; diastolic (D) BP 69.6±7.7 mmHg), normoglycemic, non-obese, otherwise healthy adults (mean age 48 ± 10 yrs, 50% female).

Methods: IR was assessed with HOMA-Index and subjects were classified into IR tertiles, based on the distribution of HOMA-index values. Recordings of pulse waveform were obtained by means of a validated oscillometric device (Mobil-O-Graph NG, IEM, Stolberg, Germany) for ambulatory BP monitoring with in-built transfer-function like method. Aortic pulse wave velocity (PWV, m/s) and other measures derived from pulse wave analysis such as augmentation index (AIx, %), central SBP (cSBP), central DBP (cDBP) and central pulse pressure (cPP) were computed. Peripheral SBP and DBP, and heart rate (HR) were recorded and pulse pressure (PP) calculated as the difference between SBP and DBP.

Results: After multiple regression analysis adjusting for age, sex, HR and BMI, there was a significant overall effect of IR on measures of large artery stiffness and in central and peripheral BP levels. IR was associated with increased aortic PWV, and with higher central and peripheral SBP and DBP levels. See table.

Hemodynamic variables by tertiles of HOMA index*
Variable T1 (<0.94) (n=32) T2 (0.94–1.90) (n=28) T3 (>1.90) (n=30) P value
Peripheral SBP (mmHg) 111.7 ± 2.0 114.3 ± 1.8 123.2 ± 2.0 <0.0001
Peripheral DBP (mmHg) 76.8 ± 1.4 79.8 ± 1.3 84.7 ± 1.5 0.001
Peripheral PP (mmHg) 33.5 ± 1.0 35.0 ± 0.9 38.4 ± 1.0 0.004
Central SBP (mmHg) 103.7 ± 1.7 106.7 ± 1.5 115.3 ± 1.6 0.001
Central DBP (mmHg) 77.8 ± 1.5 81.1 ± 1.3 86.1 ± 1.5 0.001
Central PP (mmHg) 25.5 ± 1.5 25.1 ± 1.3 29.2 ± 1.0 0.071
MBP (mmHg) 92.5 ± 1.5 95.7 ± 1.3 102.3 ± 1.5 <0.0001
HR (bpm) 61.3 ± 1.9 65.0 ± 1.7 66.0 ± 1.9 0.212
PWV (m/s) 5.64 ± 0.17 5.71 ± 0.10 6.34 ± 0.9 0.012
Augmentation Index (%) 6.7 ± 3.2 6.1 ± 3.8 6.9 ± 2.2 0.082
*

Values are expressed as means ± SEM

Conclusion: our results indicate that in normotensive, healthy adults, IR may induce significant increases in large artery stiffness (as assessed with aortic PWV) and in central and peripheral BP levels.

Journal
Artery Research
Volume-Issue
6 - 4
Pages
187 - 188
Publication Date
2012/11/17
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
https://doi.org/10.1016/j.artres.2012.09.164How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - J.E. Ochoa
AU  - M.M. Correa
AU  - A.M. Valencia
AU  - J.G. McEwen
AU  - J.A. Gallo
AU  - G. Bilo
AU  - P. Salvi
AU  - D. Aristizabal
AU  - G. Parati
PY  - 2012
DA  - 2012/11/17
TI  - P4.16 INSULIN RESISTANCE IS ASSOCIATED WITH INCREASED LARGE ARTERY STIFFNESS IN NORMOTENSIVE HEALTHY ADULTS
JO  - Artery Research
SP  - 187
EP  - 188
VL  - 6
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2012.09.164
DO  - https://doi.org/10.1016/j.artres.2012.09.164
ID  - Ochoa2012
ER  -