P4.36 EFFECTS OF HYPEROXIA ON THE RELATIONSHIP BETWEEN HEART RATE VARIABILITY, BLOOD PRESSURE AND ARTERIAL WALL PROPERTIES IN HEALTHY SUBJECTS
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- 10.1016/j.artres.2012.09.183How to use a DOI?
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Objective: Previous studies reported that normobaric hyperoxia impacts heart rate, arterial pressure, cardiac output and systemic vascular resistance, but the mechanism of changes is not fully understood. Therefore, the aim of our study was to examine heart rate variability (as a potential indicator of autonomic balance) and its relation to vascular tone and blood pressure in healthy volunteers during air and oxygen breathing.
Methods: In 12 healthy subjects (5 men; age 33.8±7.4 years) we assessed heart rate variability (HRV) and the relation between HRV parameters and blood pressure, respiratory frequency (PowerLab), common carotid artery diameter, wall distensibility and local pulse wave velocity (ArtLab System), changes in the digital pulse waveform (EndoPAT), stroke index and systemic vascular resistance (HOTMAN) during medical air (MAB) and 100% oxygen breathing (OXB).
Results: HRV parameters did not differ during MAB and OXB. However, the correlations between HRV and other parameters varied substantially during MAB and OXB. During MAB mean and systolic blood pressure, carotid artery diameter, reactive hyperemia index and mean arterial tone signal of finger artery correlated linearly with spectral HRV components while during OXB the above relations disappeared. In turn, augmentation index of finger artery, stroke index and systemic vascular resistance correlated during MAB with different HRV spectral parameters than during OXB.
Conclusion: Correlations of HRV and hemodynamic parameters reveal additional information regarding the effect of short-term hyperoxia. Our findings suggest that during OXB the regulation of blood pressure and vascular tone is mostly mediated by other factors than autonomic nervous system alterations.
| SIGNIFICANT LINEAR CORRELATIONS OF SPECTRAL HRV PARAMETERS | ||
|---|---|---|
| MEDICAL AIR | OXYGEN | |
| Mean arterial pressure | VLF [%] (R= −0.78), LF [%] (R=0.77) | (-) |
| Systolic blood pressure | VLF [%] (R= −0.69), LF [%] (R=0.72), LF/HF (R=0.62) | (-) |
| Carotid artery diameter | LF [%] (R=0.74) | (-) |
| Mean arterial tone signal of finger artery | LF [%] (R=0.74) | (-) |
| Reactive hyperemia index of finger artery | LF [ms2] (R=0.65) | (-) |
| Augmentation index of finger artery | HF [%] (R=0.66) | VLF [%] (R=0.64) LF [%] (R= −0.64) |
| Stroke index | LF [ms2] (R=0.63) | HF [%] (R=0.59) |
| Systemic vascular resistance | VLF [ms2] (R= −0.64) | HF [%] (R= −0.59) |
Cite this article
TY - JOUR AU - B. Graff AU - A. Szyndler AU - K. Czechowicz AU - W. Kucharska AU - P. Boutouyrie AU - S. Laurent AU - K. Narkiewicz PY - 2012 DA - 2012/11/17 TI - P4.36 EFFECTS OF HYPEROXIA ON THE RELATIONSHIP BETWEEN HEART RATE VARIABILITY, BLOOD PRESSURE AND ARTERIAL WALL PROPERTIES IN HEALTHY SUBJECTS JO - Artery Research SP - 193 EP - 193 VL - 6 IS - 4 SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2012.09.183 DO - 10.1016/j.artres.2012.09.183 ID - Graff2012 ER -