Artery Research

Volume 6, Issue 4, December 2012, Pages 194 - 194

P4.40 CARDIOVASCULAR DISEASE AFTER PEDIATRIC RENAL TRANSPLANTATION

Authors
E. Kis1, O. Cseprekal2, A.A. Degi1, A. Kerti1, P. Sallay1, A.J. Szabo1, Gy Reusz1
11st Department of Pediatrics, Semmelweis University, Budapest, Hungary
21st Department of Internal Medicine, Semmelweis University, Budapest, Hungary
Available Online 17 November 2012.
DOI
10.1016/j.artres.2012.09.187How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Background: Chronic kidney disease is associated with an increased arterial stiffness (Ast) and left ventricular (LVM) mass. Increased ASt results in an elevated pulse wave velocity (PWV). Few data are available on the evolution of PWV and LVM following renal transplantation (RTX) in children.

Aim, subjects, Methods: Children (aged 13,4 (0,88) years /mean(SD)/) with end stage renal disease followed by successful RTX were identified. 26 patients underwent PWV measurement 2,81 (0,03) years after RTx, with repeat PWV measurement and echocardiography 3,5 (1,08) years after transplantation. The LVM index (LVMi) was calculated. PWV was measured by applanation tonometry. Age and height matched PWV normal values were used, SD score was calculated. Candidate clinical variables for an association with LVMi and PWV were assessed, including age, rutine laboratory findings, medications (serum levels and cumulative doses) and co-morbidities (hypertension, diabetes, dyslipidaemia).

Results: PWV age SDS (1,18(1,22)) and PWV height SDS (1,47 (1,21)) of RTx were increased compared to healthy pediatric population. Follow up measurement of PWV revealed increased PWV age SDS (1,18 vs 0,19) 3.5 years after RTx. Follow up measurement of PWV age SDS correlated with LVMi (r: 0,61, p:0,01). There was a bimodal correlation between LVMi and cumulative calcitriol dose before RTx.

Conclusion: Controls matched both for age and height should be used to assess PWV in RTx children with growth failure. Ast determined by PWV increased after RTx, and correlated with left ventricular hypertrophy (LVMi). Cumulative dose of calcitriol is among the major determinants of left ventricular hypertrophy after Tx.

Journal
Artery Research
Volume-Issue
6 - 4
Pages
194 - 194
Publication Date
2012/11/17
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2012.09.187How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - E. Kis
AU  - O. Cseprekal
AU  - A.A. Degi
AU  - A. Kerti
AU  - P. Sallay
AU  - A.J. Szabo
AU  - Gy Reusz
PY  - 2012
DA  - 2012/11/17
TI  - P4.40 CARDIOVASCULAR DISEASE AFTER PEDIATRIC RENAL TRANSPLANTATION
JO  - Artery Research
SP  - 194
EP  - 194
VL  - 6
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2012.09.187
DO  - 10.1016/j.artres.2012.09.187
ID  - Kis2012
ER  -