Artery Research

Volume 6, Issue 4, December 2012, Pages 190 - 191

P4.27 AUTONOMIC NERVOUS SYSTEM REACTIVITY IN NORMOTENSIVE SUBJECTS WITH A FAMILY HISTORY OF HYPERTENSION DURING VALSALVA MANOEUVRE

Authors
K. Cankar, Z. Melik, M. Strucl
University of Ljubljana, Medical Faculty, Insitute of Physiology, Zaloska 4; 1000 Ljubljana, Ljubljana, Slovenia
Available Online 17 November 2012.
DOI
10.1016/j.artres.2012.09.174How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Introduction: This study was designed to address alterations in autonomic nervous system activity in normotensive subjects with a family history of hypertension. We compared the autonomic nervous system activity in 11 normotensives with a family history of hypertension (age 23.3 ± 0.4) and 14 normotensives with no family history of hypertension (age 22.9 ± 0.3).

Methods: In all of the participants their cardiovascular parameters, including impedance cardiography, were measured at rest. In addition, the Valsalva manoeuvre was performed and Valsalva Index was obtained. On the basis of the arterial blood pressure change, provoked by the Valsalva manoeuvre, the latency of baroreflex response was determined.

Results: Normotensives subjects with a family history of hypertension, compared to the control group, showed significantly higher heart rate (75.0 ± 3.4 vs. 62.4 ± 1.8 beats/min), cardiac output (7.6 ± 0.4 vs. 6.7 ± 0.3 L/min), left ventricular weight index (4.6 ± 0.3 vs. 3.9 ± 0.1) and shorter ejection time (298.9 ± 4.9ms vs. 316.8 ± 4.5ms) (t-test, p< 0.05). In addition, the normotensives with a family history of hypertension have decreased latency of the baroreflex response (7.0 ± 0.5 s) compared to the control group (10.5 ± 0.9 s) (p<0.001).

Conclusions: Our results indicate that even normotensives with a family history of hypertension exhibit changes of some cardiovascular parameters at early age. The changes in Valsalva manoeuvre response also show alteration of the autonomic nervous system reactivity.

Journal
Artery Research
Volume-Issue
6 - 4
Pages
190 - 191
Publication Date
2012/11/17
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2012.09.174How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - K. Cankar
AU  - Z. Melik
AU  - M. Strucl
PY  - 2012
DA  - 2012/11/17
TI  - P4.27 AUTONOMIC NERVOUS SYSTEM REACTIVITY IN NORMOTENSIVE SUBJECTS WITH A FAMILY HISTORY OF HYPERTENSION DURING VALSALVA MANOEUVRE
JO  - Artery Research
SP  - 190
EP  - 191
VL  - 6
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2012.09.174
DO  - 10.1016/j.artres.2012.09.174
ID  - Cankar2012
ER  -