P4.32 HAEMODYNAMIC PATTERN OF OBESE PATIENTS ON PRIMARY CARDIOVASCULAR PREVENTION
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- 10.1016/j.artres.2012.09.179How to use a DOI?
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Background: Impedance Cardiography (ICG) is a non-invasive method to assess the main haemodynamic parameters: cardiac output, peripheral resistance, cardiac work, and thoracic fluid content. There is no agreement about the haemodynamic pattern in obese patients and it is very important at the time to decide adecuate therapeutic interventions.
Objective: To study the haemodynamic pattern in obese patients
Methods: We compared 95 male obese patients with 212 matched male lean controls between DEC2010 and JAN2011 derived for routine cardiovascular evaluation without history of CV disease, for Primary CV Prevention. We used an Impedance Cardiograph (Z Logic (R)) following standard procedures.
Results: (only signif.) Obese patients presented higher BP, HR, BMI and BSA. They had increased Thoracic Fluid Content and higher Peripheral Resistance Index and reduced Aortic compliance.
Cardiac Index and cardiac acceleration index were lower and pre-ejective period was longer in the obese group.(see table attached)
Conclusion: Obese patients compared with matched controls present increased thoracic fluid content, peripheral vascular resistance and aortic stiffness associated with depression of cardiac function. This pattern may be associated to early stages of ventriculo arterial uncoupling and increased CV risk.
| PARAMETERS | LEAN (n=212) | OBESE (n= 95) | SIGNIF |
|---|---|---|---|
| AGE (yrs) | 50,1 ± 5,7 | 50,1 ± 5,8 | NS |
| WEIGHT (kgs) | 82,1 ± 8,3 | 102,2 ± 11,9 | <0.001 |
| HEIGHT (cms) | 176,6 ± 6,1 | 175,9 ± 6,9 | NS |
| BMI (Kg/m2) | 26,3 ± 1,8 | 33 ± 3,1 | <0.001 |
| BSA (m2) | 2 ± 0,1 | 2,2 ± 0,2 | <0.001 |
| SBP (mmHg) | 132 ± 17,5 | 140 ± 16,4 | <0.001 |
| DBP (mmHg) | 82,3 ± 11,1 | 88 ± 9,3 | <0.001 |
| HR (bpm) | 59,2 ± 10,1 | 63 ± 11,2 | .003 |
| THOR IMP (Z0) (Ohms) | 23,9 ± 2,2 | 22,6 ± 2,5 | <0.001 |
| TFC (kohms. (−1)) | 42,1 ± 3,9 | 44,7 ± 5 | <0.001 |
| CO (l/min) | 4,8 ± 1,3 | 4,7 ± 1 | NS |
| CI (l/min /m2) | 2,5 ± 1 | 2,2 ± 0,6 | 0.001 |
| PVR (dyn.seg.cm−5) | 1683,9 ± 528,3 | 1855,2 ± 643,3 | 0.024 |
| PVRI (dyn.seg.cm−5.m2) | 3341,8 ± 1074,3 | 4016 ± 1482,1 | <0.001 |
| PREEJECT P (mseg) | 119 ± 21,6 | 127,6 ± 18 | <0.001 |
| EJECTIVE P (mseg) | 324,4 ± 33,3 | 312,4 ± 42,5 | 0.016 |
| CARD ACC IND (1000.seg) | 68,3 ± 15,3 | 59,8 ± 14,1 | <0.001 |
| AO COMPL (ml/mmHg) | 1,8 ± 0,7 | 1,6 ± 0,6 | 0.011 |
Ref: Thor Imp: Thoracic Impedance TFC: Thoracic Fluid Content CO: Cardiac Output CI: Cardiac Index PVR: Peripheral Vascular Resistance PVRI: Peripheral Vascular Resistance Index Preeject P: Preejective Period Ejective P: Ejective Period Card Acc Ind: Systolic Acceleration Index Ao Compl: Aortic Compliance (Zc)
Cite this article
TY - JOUR AU - P. Forcada AU - D. Olano AU - S. Obregon AU - S. Gonzalez AU - J. Chiabaut AU - C. Castelllaro AU - F. Inserra AU - C. Kotliar PY - 2012 DA - 2012/11/17 TI - P4.32 HAEMODYNAMIC PATTERN OF OBESE PATIENTS ON PRIMARY CARDIOVASCULAR PREVENTION JO - Artery Research SP - 192 EP - 192 VL - 6 IS - 4 SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2012.09.179 DO - 10.1016/j.artres.2012.09.179 ID - Forcada2012 ER -