Artery Research

Volume 6, Issue 4, December 2012, Pages 196 - 197

P4.50 EFFICACY OF THE COMBINATION OF β-BLOCKER BISOPROLOL AND IF INHIBITOR IVABRADINE IN PATIENTS WITH STABLE ANGINA AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Authors
G. Makarova1, I.A. Orlova2, M. Vitsenya2, A. Kuzmina2, F. Ageev2
1Central polyklinika of FSB RF, Moscow, Russian Federation
2Russian Cardiology Researh Center, Moscow, Russian Federation
Available Online 17 November 2012.
DOI
10.1016/j.artres.2012.09.197How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

The study was aimed to assess the efficacy and safety of treating coronary heart disease (CHD) patients complicated with Chronic Obstructive Pulmonary Disease (COPD) using the combination of tolerable doses of beta-blocker bisoprolol and inhibitor If-channel ivabradine, compared with bisoprolol alone. PARICIPANTS. 50 patients with stable angina and COPD were included (88% men, mean age 62.8±7.2 years). All patients received bisoprolol, the dose of which was titrated until the clinical signs of intolerance. Then, the patients were randomized into two groups: patients of the first group continued to take bisoprolol and patients of the second group were added ivabradine (5–15 mg).

Results: Combination therapy resulted in further decrease of heart rate (HR) to an average of 62±4 bpm over 6 month of follow–up. This was associated with additional decrease of the number of angina attacks (by 4.7±4.4 per week vs. 2.5±4.7, p<0.05) and increase of quality of life (p<0.05). Only in combination therapy group there was also the decrease of broncholytics consumption (from 2.9±3.2 to 1.9±2.7 per week, p<0.05). Pulse wave velocity (PWV) estimated by Arteriograph (TensioClinic «Meditech») decrease significant in both groups, but no difference delta PWV between groups.

Conclusion: The combination of tolerable doses of bisoprolol and ivabradine is safe and allows to achieve adequate HR decrease. This is associated with maximal antianginal effect, decrease in the need for broncholytic therapy, improvement of the quality of life compared with the treatment with bisoprolol alone. We did not find the influences of ivabradine on the arterial stiffness.

Journal
Artery Research
Volume-Issue
6 - 4
Pages
196 - 197
Publication Date
2012/11/17
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2012.09.197How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - G. Makarova
AU  - I.A. Orlova
AU  - M. Vitsenya
AU  - A. Kuzmina
AU  - F. Ageev
PY  - 2012
DA  - 2012/11/17
TI  - P4.50 EFFICACY OF THE COMBINATION OF β-BLOCKER BISOPROLOL AND IF INHIBITOR IVABRADINE IN PATIENTS WITH STABLE ANGINA AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE
JO  - Artery Research
SP  - 196
EP  - 197
VL  - 6
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2012.09.197
DO  - 10.1016/j.artres.2012.09.197
ID  - Makarova2012
ER  -