Artery Research

Volume 1, Issue 2, September 2007, Pages 48 - 49

05.02 HERITABILITY AND INTRAFAMILIAL AGGREGATION OF ARTERIAL CHARACTERISTICS

Authors
J.S. Seidlerova1, J.A.S. Staessen1, M.B. Bochud2, M.C. Cwynar3, M.D. Dolejsova4, T.K. Kuznetsova1, T.N. Nawrot1, A.O. Olszanecka3, K.S. Stolarz3, L.T. Thijs1, W.W. Wojciechowska3, HAS.-B. Struijker-Boudier5, KK.-J. Kawecka-Jaszcz3, R.C.E. Elston6, R.F. Fagard1, J.F. Filipovsky4
1Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
2Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
3The First Department of Cardiology and Hypertension, Jagiellonian University Medical College, Cracow, Poland
4The Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic
5The Department of Pharmacology and Toxicology, Cardiovascular Research Institute, Maastricht, Netherlands
6Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, USA
Available Online 30 August 2007.
DOI
10.1016/j.artres.2007.07.043How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Background: We investigated in the same subjects, heritability and familial aggregation of various indexes of arterial stiffness and we partitioned the phenotypic correlation between these traits into shared genetic and environmental components.

Methods: Using a family-based random sampling frame, we recruited 204 parents (mean age, 51.7 years) and 290 offspring (29.4 years) from the population in Cracow, Poland (62 families), Hechtel-Eksel, Belgium (36), and Pilsen, the Czech Republic (50). We measured peripheral pulse pressure (PPp) sphygmomanometrically at the brachial artery; central pulse pressure (PPc), the peripheral (PAIx) and central (CAIx) augmentation indexes by tonometry at the radial artery; and aortic pulse wave velocity (PWV) by tonometry or ultrasound. In multivariate-adjusted analyses, we used the ASSOC and PROC GENMOD procedures as implemented in S.A.G.E. and SAS, respectively.

Results: All traits, with the exception of PPc (P=0.79) and PWV (P=0.08), showed significant heritability (P≤0.0001), ranging from 0.37 for PPp to 0.41 for CAIx. The genetic correlation between PWV and the other arterial indexes were significant (ρG≥0.29; P<0.0001). The corresponding environmental correlations were only significantly positive for PPp (ρE=0.10, P=0.03). Intrafamilial concordance was significant for all arterial indexes (r≥0.12; P≤0.02), with the exception of PPc (r=−0.007; P=0.90) in parent-offspring pairs. The sib-sib correlations were also significant for CAIx (r=0.22; P=0.001).

Conclusion: The observation in the same group of subjects of significant intrafamilial concordance and heritability of various indexes of arterial stiffness as well as the genetic correlations among arterial phenotypes strongly support the search for shared genetic determinants underlying these traits.

All traits, with the exception of PPc (P=0.79) and PWV (P=0.08), showed significant heritability (P≤0.0001), ranging from 0.37 for PPp to 0.41 for CAIx. The genetic correlation between PWV and the other arterial indexes were significant (ρG≥0.29; P<0.0001). The corresponding environmental correlations were only significantly positive for PPp (ρE=0.10, P=0.03). Intrafamilial concordance was significant for all arterial indexes (r≥0.12; P≤0.02), with the exception of PPc (r=−0.007; P=0.90) in parent-offspring pairs. The sib-sib correlations were also significant for CAIx (r=0.22; P=0.001).

The observation in the same group of subjects of significant intrafamilial concordance and heritability of various indexes of arterial stiffness as well as the genetic correlations among arterial phenotypes strongly support the search for shared genetic determinants underlying these traits.

Journal
Artery Research
Volume-Issue
1 - 2
Pages
48 - 49
Publication Date
2007/08/30
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2007.07.043How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - J.S. Seidlerova
AU  - J.A.S. Staessen
AU  - M.B. Bochud
AU  - M.C. Cwynar
AU  - M.D. Dolejsova
AU  - T.K. Kuznetsova
AU  - T.N. Nawrot
AU  - A.O. Olszanecka
AU  - K.S. Stolarz
AU  - L.T. Thijs
AU  - W.W. Wojciechowska
AU  - HAS.-B. Struijker-Boudier
AU  - KK.-J. Kawecka-Jaszcz
AU  - R.C.E. Elston
AU  - R.F. Fagard
AU  - J.F. Filipovsky
PY  - 2007
DA  - 2007/08/30
TI  - 05.02 HERITABILITY AND INTRAFAMILIAL AGGREGATION OF ARTERIAL CHARACTERISTICS
JO  - Artery Research
SP  - 48
EP  - 49
VL  - 1
IS  - 2
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2007.07.043
DO  - 10.1016/j.artres.2007.07.043
ID  - Seidlerova2007
ER  -