Artery Research

Volume 1, Issue S1, June 2006, Pages S30 - S30

P.009 ATORVASTATIN ABROGATES THE DETERIORATION OF ENDOTHELIAL FUNCTION INDUCED BY ACUTE INFLAMMATION IN DYSLIPIDEMIC PATIENTS

Authors
C. Vlachopoulos, A. Dagre, K. Aznaouridis*, C. Masoura, J. Skoumas, C. Pitsavos, C. Stefanadis
Available Online 13 June 2007.
DOI
10.1016/S1872-9312(07)70032-7How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Introduction: Acute inflammation is associated with a deterioration of endothelial function. Statins reduce cardiovascular risk by lipid lowering and non-lipid pleiotropic effects. It has not been defined whether atorvastatin modifies the effects of acute inflammation on endothelial function in dyslipidemic patients.

Methods: We generated a transient systemic inflammation by Salmonella Typhi vaccination in 30 volunteers with mild dyslipidemia. They were studied 4 days after randomly taking atorvastatin 40 mg or placebo once daily at bedtime. Conduit artery endothelial performance was assessed before and 8 hours after vaccination. Flow-mediated dilation (FMD) of the brachial artery, an index of endothelial function, and the endothelium-independent nitrate-induced dilation (NID) were measured by using high resolution ultrasonography.

Results: There were no differences in all baseline characteristics among the two groups. In the placebo group, vaccination caused a significant decrease of FMD at 8 hours (by 2.65±1.08%, P < 0.05, left figure), indicating an unfavourable effect of inflammation on endothelial function. In contrast, in the pretreated with atorvastatin group, the decrease of FMD after vaccination (by 0.22±0.53%) was significantly smaller compared with placebo (P < 0.05 by 2-way repeated-measures ANOVA, left figure), denoting that the adverse effect of inflammation on endothelial function is abrogated by atorvastatin. We did not observe any significant change of NID after vaccination in any group (P=NS, right figure).

Conclusion: In dyslipidemic patients, atorvastatin abrogates the deterioration of endothelial function caused by an acute inflammatory stimulus. This finding provides valuable insights into the protective effect of atorvastatin on arterial function and on the cardiovascular system overall.

Journal
Artery Research
Volume-Issue
1 - S1
Pages
S30 - S30
Publication Date
2007/06/13
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/S1872-9312(07)70032-7How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - C. Vlachopoulos
AU  - A. Dagre
AU  - K. Aznaouridis*
AU  - C. Masoura
AU  - J. Skoumas
AU  - C. Pitsavos
AU  - C. Stefanadis
PY  - 2007
DA  - 2007/06/13
TI  - P.009 ATORVASTATIN ABROGATES THE DETERIORATION OF ENDOTHELIAL FUNCTION INDUCED BY ACUTE INFLAMMATION IN DYSLIPIDEMIC PATIENTS
JO  - Artery Research
SP  - S30
EP  - S30
VL  - 1
IS  - S1
SN  - 1876-4401
UR  - https://doi.org/10.1016/S1872-9312(07)70032-7
DO  - 10.1016/S1872-9312(07)70032-7
ID  - Vlachopoulos2007
ER  -