Artery Research

Volume 1, Issue S1, June 2006, Pages S31 - S31

P.013 LONGITUDINAL STUDY OF VASCULAR MARKERS OF PREMATURE ATHEROSCLEROSIS AND METABOLIC CORRELATES IN HIV-INFECTED CHILDREN

Authors
T. Bradley*, A. Bitnun, C. Slorach, C. Arneson, M. Cheung, E. Sochett, B. McCrindle, S. Read, S. King
Available Online 13 June 2007.
DOI
10.1016/S1872-9312(07)70036-4How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Purpose: To determine the presence of vascular markers of premature atherosclerosis and metabolic correlates in a prospectively followed cohort of antiretroviral treated HIV-infected children.

Methods: Vascular assessment included: carotid intima-media thickness and brachial artery reactivity using vascular ultrasound; peripheral pulse wave velocity (PWV) using photoplethysmography; central PWV, arterial stiffness and impedance indices using an Echo-Doppler method; and only at followup, augmentation index and PWV by applanation tonometry. Disease markers, oral glucose tolerance, fasting lipid profiles and abdominal fat (single slice CT scan) were also determined.

Results: Twenty children were assessed at baseline (median age 12.6 [range 8.5–18.5] years; 50% female) and follow-up 21–25 months later. All were on combination antiretroviral therapy at baseline, but 5 were off therapy at follow-up with fewer receiving protease inhibitors. Resting systolic blood pressure and pulse pressure increased significantly over the study period (both p < 0.0001), as did elastic modulus, stiffness index and input impedance (p = 0.0018, p = 0.0004, p = 0.0082, respectively). PWV measures by the different methods were not shown to correlate significantly. Dyslipidemia and abnormal glucose metabolism were present in 14 and 2 at baseline, and in 7 and 0 at follow-up, respectively. Visceral, subcutaneous and total abdominal fat content increased over time, but not significantly so.

Conclusions: An increase in measures of large arterial wall stiffness was observed over time. The reduction in dyslipidemia at follow-up may be related to fewer children receiving protease inhibitors. The potential risk of premature atherosclerosis in HIV-infected children on anti-retroviral therapy warrants long-term monitoring of metabolic profiles and vascular function.

Journal
Artery Research
Volume-Issue
1 - S1
Pages
S31 - S31
Publication Date
2007/06/13
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/S1872-9312(07)70036-4How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - T. Bradley*
AU  - A. Bitnun
AU  - C. Slorach
AU  - C. Arneson
AU  - M. Cheung
AU  - E. Sochett
AU  - B. McCrindle
AU  - S. Read
AU  - S. King
PY  - 2007
DA  - 2007/06/13
TI  - P.013 LONGITUDINAL STUDY OF VASCULAR MARKERS OF PREMATURE ATHEROSCLEROSIS AND METABOLIC CORRELATES IN HIV-INFECTED CHILDREN
JO  - Artery Research
SP  - S31
EP  - S31
VL  - 1
IS  - S1
SN  - 1876-4401
UR  - https://doi.org/10.1016/S1872-9312(07)70036-4
DO  - 10.1016/S1872-9312(07)70036-4
ID  - Bradley*2007
ER  -