Artery Research

Volume 1, Issue S1, June 2006, Pages S39 - S39

P.051 EVALUATION OF ENDOTHELIAL FUNCTION WITH NON-INVASIVE METHODS IN DIFFERENT CARDIOVASCULAR DISEASES

Authors
J. Nemcsik*, J. Egresits, J. Borvendég, E. Kolossváry, E. Finta, K. Farkas, I. Kiss
Szent Imre Teaching Hospital, Department of Angiology and Nephrology, Budapest, Hungary
Available Online 13 June 2007.
DOI
10.1016/S1872-9312(07)70074-1How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

The aim of our study was to evaluate microvascular reactivity and arterial stiffness with non-invasive methods in patients with different cardiovascular risk factors. Following blood pressure measurement, skin microcirculation was studied with laser Doppler flowmetry (Periflux 5001). The effect of local heating (LH; 44°C, 1min) and the postocclusive reactive hyperaemia (PORH; 220 mmHg, 3 min) were measured. Arterial stiffness was evaluated with the newly developed TensioClinic Arteriograf instrument which calculate the pulse wave velocity (PWV, m/s) and augmentation index (Aix, %). Healthy controls (CONT, n = 13), patients with essential hypertension (EH, n = 13), with essential hypertension and peripheral artery disease (EH+PAD, n = 22), and essential hypertension and 2-type diabetes mellitus (EH+DM, n = 25) were measured. Pulse pressure (PP) was higher in EH+PAD (62.6±3.2 mmHg, p < 0.05) and EH+DM (67.6±3.3 mmHg, p < 0.001) groups compared with CONT (52.5±3.4 mmHg). Aix, PWV and the PORH were significantly different in healthy controls (−62.11%, 7.01m/s, 393.77%, resp.) compared to the patient groups. These parameters were significantly different in the EH (−34.25%, 7.91m/s, 292.77%), EH+PAD (0.34%, 9.16m/s, 182.86%) and EH+DM groups (0.87%, 9.27m/s, 192.84%). The reactive hyperaemia for LH was significantly lower in the EH (782±106%), EH+PAD (651±53%) and EH+DM (453±45%) compared with the CONT (1049±133%). Significant correlation was found between the PORH and Aix (r = −0.54; p < 0.001) and PP and Aix (r = 0.42, p < 0.05). Using these non-invasive methods there is a growing possibility to diagnose endothelial dysfunction in patients with different cardiovascular diseases. Prospective studies are needed to evaluate the prognostic value and the utility in therapy follow-up of these methods.

Journal
Artery Research
Volume-Issue
1 - S1
Pages
S39 - S39
Publication Date
2007/06/13
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/S1872-9312(07)70074-1How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - J. Nemcsik*
AU  - J. Egresits
AU  - J. Borvendég
AU  - E. Kolossváry
AU  - E. Finta
AU  - K. Farkas
AU  - I. Kiss
PY  - 2007
DA  - 2007/06/13
TI  - P.051 EVALUATION OF ENDOTHELIAL FUNCTION WITH NON-INVASIVE METHODS IN DIFFERENT CARDIOVASCULAR DISEASES
JO  - Artery Research
SP  - S39
EP  - S39
VL  - 1
IS  - S1
SN  - 1876-4401
UR  - https://doi.org/10.1016/S1872-9312(07)70074-1
DO  - 10.1016/S1872-9312(07)70074-1
ID  - Nemcsik*2007
ER  -