Artery Research

Volume 1, Issue S1, June 2006, Pages S40 - S40

P.053 PROGNOSTIC SIGNIFICANCE OF FLOW MEDIATED DILATATION OF THE BRACHIAL ARTERY IN HYPERTENSIVE PATIENTS.

Authors
M. Salvetti*, M.L. Muiesan, A. Paini, E. Belotti, G. Galbassini, V. Paderno, C. Agabiti-Rosei, C. Aggiusti, E. Agabiti-Rosei
Internal Medicine, Brescia, Italy
Available Online 13 June 2007.
DOI
10.1016/S1872-9312(07)70076-5How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Background: In uncomplicated hypertensive patients the prognostic role of endothelial dysfunction, as evaluated by flow-mediated vasodilatation of the brachial artery, has not been investigated.

Methods: A total of 175 prospectively identified uncomplicated hypertensives (age 53±5 years, 42% women, 48 with diabetes mellitus type 2) were studied. At baseline all subjects were untreated and underwent a baseline standard laboratory examinations. A standard echocardiogram was performed for the evaluation of LV anatomy and function and patients with systolic dysfunction or LV wall motion abnormalities were excluded. Endothelial function was measured as flow-mediated dilation of the brachial artery using highresolution ultrasound.

Results: Patients were followed for 86±34 months (range 11–123 months). A first non fatal or fatal cardiovascular event occurred in 28 patients. The incidence of cardiovascular events was 1.4 and 3.1 per 100 patient-years in patients with a FMD above (n = 87) and below (n = 88) the median value, respectively (p < 0.005 by the log-rank test). In Cox analysis, controlling for age, gender, diabetes, hypercholesterolemia, smoking, and systolic BP at baseline, a low FMD conferred an increased risk of cardiovascular events (odds ratio 2.27, 95% confidence interval [CI] 1.01–5.15, p < 0.001).

Conclusions: The presence of endothelial dysfunction, as evaluated by flow-mediated vasodilatation of the brachial artery, identifies hypertensive patients at increased risk of non fatal and fatal cardiovascular events.

Journal
Artery Research
Volume-Issue
1 - S1
Pages
S40 - S40
Publication Date
2007/06/13
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/S1872-9312(07)70076-5How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - M. Salvetti*
AU  - M.L. Muiesan
AU  - A. Paini
AU  - E. Belotti
AU  - G. Galbassini
AU  - V. Paderno
AU  - C. Agabiti-Rosei
AU  - C. Aggiusti
AU  - E. Agabiti-Rosei
PY  - 2007
DA  - 2007/06/13
TI  - P.053 PROGNOSTIC SIGNIFICANCE OF FLOW MEDIATED DILATATION OF THE BRACHIAL ARTERY IN HYPERTENSIVE PATIENTS.
JO  - Artery Research
SP  - S40
EP  - S40
VL  - 1
IS  - S1
SN  - 1876-4401
UR  - https://doi.org/10.1016/S1872-9312(07)70076-5
DO  - 10.1016/S1872-9312(07)70076-5
ID  - Salvetti*2007
ER  -