Artery Research

Volume 1, Issue S1, June 2006, Pages S44 - S44

P.071 ANGIOTENSIN RECEPTOR ANTAGONISM WITH VALSARTAN DECREASES ARTERIAL STIFFNESS IN HYPERTENSIVE PATIENTS WITH METABOLIC SYNDROME

Authors
U. Rushentsova*1, A. Zinoviev2
1University Hospital, Departament of Nephrology and Hypertension, Essen, Germany,
2Hospital 25, Department of Endocrinology, Nishny Novgorod, Russia
Available Online 13 June 2007.
DOI
10.1016/S1872-9312(07)70094-7How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Background: Angiotensin II (AT II) plays a key role in the development of vascular disease. Arterial stiffness is an important, independent predictor of cardiovascular risk. We investigated the long-term effects of selective AT1receptor blockade with valsartan on arterial stiffness in patients with hypertension and metabolic syndrome (MS).

Study design and Methods: We have examined 30 patients (16 males and 14 females, aged 47±1 years, BMI 29–46 kg/m2) with the MS and mild essential hypertension in the double blind, placebo controlled study. We measured brachial blood pressure (BD, mmHg), brachial-ankle pulse wave velocity (baPWV, cm/s) and the augmentation index (Aix, %) by using tonometry, volume-plethysmography and Doppler ultrasonography before and after 20 weeks of treatment with valsartan (40 to 160 mg/day). Statistical significance was assessed by t-test or two-way ANOVA of the dose responses curves.

Results: After 20 weeks of treatment with valsartan, baPWV and Aix were reduced: mean delta systolic BP 12±1.6 mmHg (P = 0.02 vs. baseline), diastolic BP 5.1±1.8 mmHg (P < 0.0001 vs. baseline), mean BP 7.5±2.7 mmHg (P = 0.003 vs. baseline), baPWV 2.4±0.03 cm/s (P = 0.02 vs. baseline), Aix 23±8% (P = 0.002 vs. baseline). Delta baPWV was significantly higher in the group of female patients with the MS (F/M: 2.9±0.02 cm/s vs. 2.1±0.05 cm/s, P = 0.003).

Conclusion: AT1receptor antagonism reduced the arterial stiffness in hypertensive patients with MS, and may provide new therapeutic strategies for cardiovascular risk reduction.

Journal
Artery Research
Volume-Issue
1 - S1
Pages
S44 - S44
Publication Date
2007/06/13
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/S1872-9312(07)70094-7How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - U. Rushentsova*
AU  - A. Zinoviev
PY  - 2007
DA  - 2007/06/13
TI  - P.071 ANGIOTENSIN RECEPTOR ANTAGONISM WITH VALSARTAN DECREASES ARTERIAL STIFFNESS IN HYPERTENSIVE PATIENTS WITH METABOLIC SYNDROME
JO  - Artery Research
SP  - S44
EP  - S44
VL  - 1
IS  - S1
SN  - 1876-4401
UR  - https://doi.org/10.1016/S1872-9312(07)70094-7
DO  - 10.1016/S1872-9312(07)70094-7
ID  - Rushentsova*2007
ER  -