Artery Research

Volume 1, Issue S1, June 2006, Pages S41 - S42

P.060 AGE-RELATED ARTERIAL STIFFNESS IN PATIENTS WITH WHITE COAT OR ESSENTIAL HYPERTENSION

Authors
G. Vyssoulis*, S.M. Kyvelou, P. Pietri, D. Adamopoulos, C. Vlachopoulos, A. Deligeorgis, E. Gymnopoulou, C. Stefanadis
Hypertension Unit, 1st Department of Cardiology, Athens Medical School, Hippokration Hospital, Athens, Greece
Available Online 13 June 2007.
DOI
10.1016/S1872-9312(07)70083-2How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Background: It is well documented that arterial stiffness is age-related. The purpose of the present study was to evaluate to what extent age affects arterial stiffness in patients with essential or white coat hypertension (WCH) and the effect of previous antihypertensive medication.

Methods: We studied 850 patients, untreated or after a 15 days wash-out period, in our outpatient clinic. All patients underwent 24h ambulatory blood pressure monitoring (ABPM) and full biochemical assay. Large-artery stiffness and arterial wave reflections were evaluated by measuring carotid-femoral pulse wave velocity (PWVc-f) and augmentation index (AIx) respectively.

Results: Patients were classified in four groups, according to the ABPM results. 294 never treated patients with essential hypertension (group 1), 322 patients with essential hypertension after the wash-out period (group 2), 112 never-treated patients with WCH (group 3) and 322 patients with WCH after the wash-out period (group 4). Univariate analysis showed a significant correlation of age with PWVc-f in groups 1, 2 and 3 (r = 0.43, 0.46 and 0.38 respectively, p < 0.001) but not in group 4 (r = 0.17, p = NS). Furthermore, age was positively correlated with AIx in all groups (r = 0.53, 0.38, 0.47 and 0.67 respectively, p < 0.0001). Finally, significant correlation of age with systolic blood pressure was found in groups 1 and 4 (r = 0.20 and 0.30 respectively, p < 0.001) and with diastolic blood pressure in group 2 (r = 0.37, p < 0.0001).

Conclusion: Age affects arterial stiffness differentiating in PWV or AIx. In patients with essential hypertension as well as in patients with WCH, the age effect is of similar magnitude whereas the effect of previous medication use is minimal.

Journal
Artery Research
Volume-Issue
1 - S1
Pages
S41 - S42
Publication Date
2007/06/13
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/S1872-9312(07)70083-2How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - G. Vyssoulis*
AU  - S.M. Kyvelou
AU  - P. Pietri
AU  - D. Adamopoulos
AU  - C. Vlachopoulos
AU  - A. Deligeorgis
AU  - E. Gymnopoulou
AU  - C. Stefanadis
PY  - 2007
DA  - 2007/06/13
TI  - P.060 AGE-RELATED ARTERIAL STIFFNESS IN PATIENTS WITH WHITE COAT OR ESSENTIAL HYPERTENSION
JO  - Artery Research
SP  - S41
EP  - S42
VL  - 1
IS  - S1
SN  - 1876-4401
UR  - https://doi.org/10.1016/S1872-9312(07)70083-2
DO  - 10.1016/S1872-9312(07)70083-2
ID  - Vyssoulis*2007
ER  -