Artery Research

Volume 20, Issue C, December 2017, Pages 66 - 66

P38 ASCENDING AORTA DIMENSIONS AND CLINIC AND 24 HOURS BLOOD PRESSURE IN A GENERAL POPULATION IN NORTHERN ITALY: THE VOBARNO STUDY

Authors
Anna Paini, Massimo Salvetti, Fabio Bertacchini, Deborah Stassaldi, Claudia Agabiti Rosei, Carlo Aggiusti, Giulia Rubagotti, Giulia Maruelli, Chiara Arnoldi, Enrico Agabiti Rosei, Maria Lorenza Muiesan
University of Brescia, Italy
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.068How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Background: Epidemiological studies have suggested that even mild enlargement of the ascending aorta may have independent prognostic significance for cardiovascular events.

Therefore, some Authors have proposed that dilatation of the ascending aorta could be considered as a form of preclinical vascular damage in hypertensive patients.

Aim: To assess the correlation between clinic and 24 hours BP values and the dimensions of the aorta, measured at level of the sinuses of Valsalva (Val), at the left ventricular outflow tract (LVOT), and at the level of the proximal ascending aorta (AscAO) in subjects from a general population.

Methods: 250 subjects (43% males, mean age 56 ± 4 years, 42% hypertensives-HT) underwent laboratory examinations, clinic and 24 hours BP measurement, cardiac and carotid ultrasound, carotid-femoral pulse wave velocity measurement (AoPWV).

Results: aortic diameters were greater HT as compared to NT (Val: 3.41 ± 0.54 vs 3.25 ± 0.41 cm, LVOT 2.10 ± 0.28 vs 2.04±0.26, AscAo 3.39±0.45 vs 3.18±0.38, all p < 0.05). Aortic diameters were all correlated to clinic and 24 hours BP values. The coefficients of correlation were greater for 24 hours BP (Tab). Val, AscAo, LVOT were also significantly correlated with left ventricular mass (r = 0.61, r = 0.48, and r = 0.43, all p < 0.001), mean max intima media thickness (r = 0.13, r = 0.24, and r = 0.13, all p < 0.05) and with AoPWV (r = 0.16, p < 0.05, r = 0.28 p < 0.001, r = 0.08 p = ns).

Ao Valsalva Asc LVOT



r p r p r p
SBP 0.148* 0.019 0.161* 0.016 0.135* 0.037
DBP 0.253** 0.0001 0.223** 0.001 0.189** 0.003
MBP 0.220** 0.0001 0.175** 0.006 0.208** 0.002
PP −0.046 0.470 0.004 0.948 0.003 0.968
HR −0.005 0.933 −0.028 0.687 −0.004 0.949
SBP 24 hrs 0.231** 0.0001 0.162* 0.017 0.108 0.097
DBP 24 hrs 0.346** 0.0001 0.264** 0.0001 0.234** 0.0001
MBP 24 hrs 0.267** 0.0001 0.214** 0.002 0.164* 0.011
PP 24 hrs −0.003 0.962 −0.031 0.645 −0.082 0.209
HR 24 hrs −0.058 0.370 −0.051 0.454 −0.026 0.687

Conclusions: The dimensions of the proximal ascending aorta are significantly related to BP values in normotensive subjects and in hypertensive patients. Aortic dimension are more strictly related to twenty-four hours BP values than to clinic BP values. In this sample of general population, a significant correlation between aortic dimensions and measures of cardiac and vascular organ damage was also observed, confirming the parallelism between different forms of organ damage.

Journal
Artery Research
Volume-Issue
20 - C
Pages
66 - 66
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.068How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Anna Paini
AU  - Massimo Salvetti
AU  - Fabio Bertacchini
AU  - Deborah Stassaldi
AU  - Claudia Agabiti Rosei
AU  - Carlo Aggiusti
AU  - Giulia Rubagotti
AU  - Giulia Maruelli
AU  - Chiara Arnoldi
AU  - Enrico Agabiti Rosei
AU  - Maria Lorenza Muiesan
PY  - 2017
DA  - 2017/12/06
TI  - P38 ASCENDING AORTA DIMENSIONS AND CLINIC AND 24 HOURS BLOOD PRESSURE IN A GENERAL POPULATION IN NORTHERN ITALY: THE VOBARNO STUDY
JO  - Artery Research
SP  - 66
EP  - 66
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.068
DO  - 10.1016/j.artres.2017.10.068
ID  - Paini2017
ER  -