Artery Research

Volume 20, Issue C, December 2017, Pages 62 - 62

P2 LOCAL ABDOMINAL VERSUS THORACIC AORTA STIFFENING IN HYPERTENSIVE RATS UNDER EITHER NO RESTRICTION OR SALTED DIET

Authors
George Lindesay1, Neila Malti2, Christophe Ragonnet1, Marc Isabelle1, Nicole Villeneuve1, Yvonnick Bézie2, Christine Vayssettes-Courchay1
1Servier Research Institute, Cardiovascular Discovery Research Unit, Suresnes, France
2Groupe Hospitalier St Joseph, Paris, France
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.055How to use a DOI?
Abstract

Background: Hypertensive humans exhibit reduced nitric oxide bioavailability and increased salt sensitivity, both of which are related to central artery stiffening. We studied the effect of 5 week NO restriction via L-NAME treatment in spontaneously hypertensive rats (SHR) and 5% salted diet in salt-sensitive SHR (SHRSP), on the thoracic (TA) and abdominal (AA) aorta.

Methods: Ultrasonic recording of the pulsatile aortic diameter together with blood pressure allowed the measurement of diameter distension and ß-stiffness index. SHRLN and SHRSP salt were compared to their respective control normotensive rats WKY and two measurements were performed in each rat for TA and AA: at operating basal pressure and at reduced WKY matched pressure, n = 6–8. Aortic structure was then characterized by immunohistochemical analysis.

Results: At basal blood pressure, stiffness was greatly increased (range 263–330%) and distension decreased at both TA and AA in both models. At WKY-matched blood pressure and pulse pressure, AA parameters remained significantly altered whereas TA recovered to values not significantly different from WKY values.

Immunohistochemistry evaluation showed similar increases of markers of fibrosis and remodeling for AA and TA in the two models (fibronectin and its integrin alpha5-beta1 receptor, Focal Adhesion Kinase).

Conclusions: This study confirms the potency of ultrasonic derived stiffness measurements and that aortic remodeling is non-uniform along the aortic trunk. The thoracic aorta, which has an important role in dampening cardiac output appears less sensitive to salt loading and NO reduction induced stiffening. Surprisingly, fibrosis does not appear to account for these dynamic differences.

Open Access
This is an open access article distributed under the CC BY-NC license.

Journal
Artery Research
Volume-Issue
20 - C
Pages
62 - 62
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.055How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - George Lindesay
AU  - Neila Malti
AU  - Christophe Ragonnet
AU  - Marc Isabelle
AU  - Nicole Villeneuve
AU  - Yvonnick Bézie
AU  - Christine Vayssettes-Courchay
PY  - 2017
DA  - 2017/12/06
TI  - P2 LOCAL ABDOMINAL VERSUS THORACIC AORTA STIFFENING IN HYPERTENSIVE RATS UNDER EITHER NO RESTRICTION OR SALTED DIET
JO  - Artery Research
SP  - 62
EP  - 62
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.055
DO  - 10.1016/j.artres.2017.10.055
ID  - Lindesay2017
ER  -