Artery Research

Volume 20, Issue C, December 2017, Pages 82 - 83

P165 HIGHER BLOOD PRESSURE IN YOUTH IS ATTRIBUTABLE TO A COMBINATION OF HIGHER CARDIAC OUTPUT AND HIGHER TOTAL PERIPHERAL RESISTANCE

Authors
Alun Hughes1, Chloe Park1, Abigail Fraser2, Laura Howe2, Siana Jones1, Debbie Lawlor2, NIsh Chaturvedi1, George Davey Smith2
1University College London, UK
2University of Bristol, UK
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.114How to use a DOI?
Abstract

Background: It has been proposed that high blood pressure (BP) in young people is due to high cardiac output (CO) with normal total peripheral resistance (TPR) – a hyperkinetic/hyperdynamic circulation. We investigated this in a large, population- based cohort of adolescents.

Methods: The study was conducted on 2091 participants in the Avon Longitudinal Study of Parents and Children (ALSPAC), a prospective population-based birth cohort study, aged 17. BP measurement and echocardiography was performed and heart rate (HR), stroke volume (SV) and TPR calculated. Data are means (SD).

Results: Table 1 shows selected characteristics of the sample. Higher quintiles of systolic BP were associated with higher SV, higher HR and higher TPR. However, the proportional contribution made by SV, HR and TPR to mean arterial pressure differed little by systolic BP quintile (stroke volume (32–34%) heart rate (25–29%) and TPR (39–41%)).

Variable Males (n = 939) Females (n = 1152) All (n = 2091)
y (0.3) (0.3) (0.3)
kg/m2 (3.7) (4.2) (4.0)
mmHg 11)/64(8) 9)/65(7) 11)/65(8)
bpm 0 0 0
L/min 1.0) 0.8) 0.9)
ml 3 1 3
mmHg ml/min (5.9) (6.0) (6.0)

Conclusions: Higher blood pressure is attributable to a combination of higher cardiac output (i.e. SV×HR) and higher TPR in a population-based sample of adolescents. There is no evidence of a disproportionate contribution from CO at higher BP levels.

Open Access
This is an open access article distributed under the CC BY-NC license.

Journal
Artery Research
Volume-Issue
20 - C
Pages
82 - 83
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.114How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Alun Hughes
AU  - Chloe Park
AU  - Abigail Fraser
AU  - Laura Howe
AU  - Siana Jones
AU  - Debbie Lawlor
AU  - NIsh Chaturvedi
AU  - George Davey Smith
PY  - 2017
DA  - 2017/12/06
TI  - P165 HIGHER BLOOD PRESSURE IN YOUTH IS ATTRIBUTABLE TO A COMBINATION OF HIGHER CARDIAC OUTPUT AND HIGHER TOTAL PERIPHERAL RESISTANCE
JO  - Artery Research
SP  - 82
EP  - 83
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.114
DO  - 10.1016/j.artres.2017.10.114
ID  - Hughes2017
ER  -