Artery Research

Volume 16, Issue C, December 2016, Pages 56 - 57

5.1 MILD REDUCTION OF GLOMERULAR FILTRATION RATE IS ASSOCIATED WITH INCREASED SYSTEMIC VASCULAR RESISTANCE INDEPENDENT OF CHANGES IN CARDIAC AUTONOMIC TONE

Authors
Ilkka Porsti2, Kati Vaaraniemi3, Pauliina Kangas1, Antti Tikkakoski2, Jenni Koskela2, Anna Tahvanainen2, Arttu Eraranta1, Jukka Mustonen2
1University of Tampere, Finland
2Tampere University Hospital, Tampere, Finland
3Central Hospital of Central Finland, Jyvaskyla, Finland
Available Online 24 November 2016.
DOI
10.1016/j.artres.2016.10.029How to use a DOI?
Abstract

Objective: Our aim was to evaluate the influence of mild impairment in kidney function on hemodynamics and cardiac autonomic tone.

Methods: We studied 561 (50% male) normotensive and hypertensive subjects without kidney or other cardiovascular diseases or antihypertensive treatment. Supine and upright hemodynamics were recorded using continuous pulse wave analysis, whole body impedance cardiography and heart rate variability analysis. Estimated glomerular filtration rate (eGFR) was calculated using the CKD-EPI cystatin C equation.

Results: Mean eGFR was 99 (range 53–152) ml/min/1.73 m2 and one third of the patients had values below 90. After adjustments for age, sex, body mass index and low density lipoprotein cholesterol level, regression analysis indicated significant associations between lower eGFR and higher systolic (p<0.001) and diastolic blood pressure (p<0.001) and systemic vascular resistance (p=0.001) regardless of body position. Lower eGFR was associated with higher low frequency to high frequency ratio of heart rate variability in supine but not in upright position. The level of eGFR was not associated with the level of cardiac output.

Conclusions: Even mild kidney impairment is associated with higher systemic vascular resistance and increased supine sympathovagal balance. However, changes in autonomic tone, as based on analysis of heart rate variability, do not seem to explain the relation between lower eGFR and higher systemic vascular resistance in the upright position. The close relationship between the regulation of GFR and systemic vascular resistance may play a role in the pathogenesis of primary hypertension.

Open Access
This is an open access article distributed under the CC BY-NC license.

Journal
Artery Research
Volume-Issue
16 - C
Pages
56 - 57
Publication Date
2016/11/24
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2016.10.029How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Ilkka Porsti
AU  - Kati Vaaraniemi
AU  - Pauliina Kangas
AU  - Antti Tikkakoski
AU  - Jenni Koskela
AU  - Anna Tahvanainen
AU  - Arttu Eraranta
AU  - Jukka Mustonen
PY  - 2016
DA  - 2016/11/24
TI  - 5.1 MILD REDUCTION OF GLOMERULAR FILTRATION RATE IS ASSOCIATED WITH INCREASED SYSTEMIC VASCULAR RESISTANCE INDEPENDENT OF CHANGES IN CARDIAC AUTONOMIC TONE
JO  - Artery Research
SP  - 56
EP  - 57
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.10.029
DO  - 10.1016/j.artres.2016.10.029
ID  - Porsti2016
ER  -