Artery Research

Volume 16, Issue C, December 2016, Pages 57 - 57

5.3 REVERSIBILITY OF ARTERIAL STIFFNESS AFTER KIDNEY TRANSPLANTATION: SYSTEMATIC REVIEW AND META-ANALYSIS

Authors
Aboubacar Sidibe, Catherine Fortier, Marie-Pier Desjardins, Fabrice Mac-Way, Sacha De Serres, Mohsen Agharazii
Centre de Recherche du CHU de Quebec, Division of Nephrology, Faculty of Medicine, Department of Medicine and Social and Preventive Medicine, Université Laval, Quebec City, Canada
Available Online 24 November 2016.
DOI
10.1016/j.artres.2016.10.031How to use a DOI?
Abstract

Background: Chronic kidney disease is associated with increased arterial stiffness. Correction of the uremic milieu by kidney transplantation (KTx) may be improve arterial stiffness. However, results from clinical studies are not uniformly convincing. This could be related to small sample size of studies, heterogeneity in methods and timing of assessment of arterial stiffness after KTx. We aim to measure the reversibility of arterial stiffness after KTx.

Design and Method: Observational studies and randomized controlled trials with measurements of pulse wave velocity (PWV), pulse pressure (PP) and/or augmentation index (AIx) were extracted from MEDLINE, EMBASE, COCHRANE LIBRARY, and Web of Science from their inception to January 2016. Two reviewers independently identified eligible studies comparing PW, PP and/or AIx pre to post KTx and extracted data including population characteristics, interventions and outcomes.

Results: 13 studies of 981 met our inclusion criteria. 11 Studies (408 renal transplant) have been included in meta-analysis. There was a standard mean change of PWV by −0.45 (95% CI: − 0.68 −0.20, I2=58%) post-KTx. Both studies using aortic PWV (5 studies, 160 patients) and those using brachial-ankle PWV, showed a significant decrease of PWV by −1.58 m/s (95% CI: −2.97 − 0.19, I2= 87%) and by −1.21 m/s (95% CI: − 1.89 – 0.54, I2=0 %) post-KTx, respectively. Analysis of central PP and AIx showed significant reduction post-KTx by −4.77 (95% CI: −9.19 −0.35, I2=55%) and by −11.59 (95% CI:-15.64 −7.53, I2=43%), respectively. Only two studies have reported adjusted parameters for mean arterial pressure.

Conclusions: There is a significant reduction in PWV, central PP and AIx after KTx. Heterogeneity among studies are globally moderate. Further analysis is required to examine the importance of changes in different vascular beds taking into account changes in blood pressure.

Open Access
This is an open access article distributed under the CC BY-NC license.

Journal
Artery Research
Volume-Issue
16 - C
Pages
57 - 57
Publication Date
2016/11/24
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2016.10.031How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Aboubacar Sidibe
AU  - Catherine Fortier
AU  - Marie-Pier Desjardins
AU  - Fabrice Mac-Way
AU  - Sacha De Serres
AU  - Mohsen Agharazii
PY  - 2016
DA  - 2016/11/24
TI  - 5.3 REVERSIBILITY OF ARTERIAL STIFFNESS AFTER KIDNEY TRANSPLANTATION: SYSTEMATIC REVIEW AND META-ANALYSIS
JO  - Artery Research
SP  - 57
EP  - 57
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.10.031
DO  - 10.1016/j.artres.2016.10.031
ID  - Sidibe2016
ER  -