Artery Research

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Volume 16, Issue C, December 2016, Pages 59 - 59

6.1 PERIPHERAL ARTERY DISEASE AND CENTRAL HEMODYNAMIC MODIFICATION

Authors
Mariella Catalano, Gabriel Dimitrov, Giovanni Scandale, Marzio Minola, Martino Recchia, Francesca Galli, Maria Carotta, Gianni Carzaniga
Research Center on Vascular Diseases and Angiology Unit, University of Milan, Italy
Available Online 24 November 2016.
DOI
10.1016/j.artres.2016.10.037How to use a DOI?
Abstract

Peripheral arterial disease (PAD) affects the hemodynamics of the lower limbs1 and is associated with increased cardiovascular risk and mortality2. The aim of this study was to evaluate central hemodynamics and to test the relationships between lower ankle-pressure index (ABI) and Augmentation index (Aix)3,4.In 242 PAD patients (mean age 67±9.8years),Augmentation index (Aix) carotid-femoral pulse wave velocity (c-fPWV), pulse pressure amplification (PPA) aortic pulse pressure (aPP) and subendocardial viability ratio (SEVR) weremeasured using applanation tonometry5,6.The ABI values were obtained using an 8-mHz Doppler probe7.c-fPWVwas similar (0.164) in both sexes, AIx was higher (p <.0001), aPPwas marginally higher (p=0.062) PPA and SEVR were lower (p= 0.013), (p<.0001) in women with PAD In the multiple regression model Aix was associated with MAP (p<.0001), age (p=0.0003), smoking history (p=0.013), cfPWV (p=0.016) diabetes (p=0.039) and female sex (p = 0.050). In this large PAD populationAix is increased in women with PAD but is not associated with a lower ABI. Furthermore, it remains uncertain whether Aix in women with PAD provides more information concerning the prognosis of these high-risk patients.

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References

1.AT Hirsch, ZJ Haskal, NR Hertzer, et al., ACC/AHA 2005 guidelines for the management of patients with peripheral arterial disease (lower extremity, renal, mesenteric, and abdominal aortic), J Am Coll Cardiol, Vol. 47, 2006, pp. 1-192.
2.FG Fowkes, GD Murray, I Butcher, et al., Ankle brachial index combined with Framingham Risk Score to predict cardiovascular events and mortality: a meta-analysis, JAMA, Vol. 300, 2008, pp. 197-208.
3.SW Rabkin, SH Chan, and C Sweeney, Ankle-brachial index as an indicator of arterial stiffness in patients without peripheral arterial disease, Angiology, Vol. 63, 2012, pp. 150-154.
4.M Khaleghi and IJ Kullo, Aortic augmentation index is associated with the ankle-brachial index: a community-based study, Atherosclerosis, Vol. 195, 2007, pp. 248-253.
5.S Laurent, J Cockcroft, L van Bortel, et al., on behalf of the European network for Non-invasive investigation of large Arteries, Expert Consensus on arterial stiffness: methodological issues and clinical applications, Eur Heart J, Vol. 27, 2006, pp. 2588-2605.
6.W Nichols and M O’Rourke, Wave reflections, W Nichols and M O’Rourke (editors), McDonald’s Blood Flow in Arteries: Theoretical, Experimental andClinical Principles, Hodder Arnold, London, United Kingdom, 2005.
7.L Norgren, WR Hiatt, JA Dormandy, MR Nehler, KA Harris, and FG Fowkes, on behalf of the TASC II Working Group, Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II), Eur J Vasc Endovasc Surg, Vol. 33, 2007, pp. 1-75.
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Journal
Artery Research
Volume-Issue
16 - C
Pages
59 - 59
Publication Date
2016/11/24
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2016.10.037How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Mariella Catalano
AU  - Gabriel Dimitrov
AU  - Giovanni Scandale
AU  - Marzio Minola
AU  - Martino Recchia
AU  - Francesca Galli
AU  - Maria Carotta
AU  - Gianni Carzaniga
PY  - 2016
DA  - 2016/11/24
TI  - 6.1 PERIPHERAL ARTERY DISEASE AND CENTRAL HEMODYNAMIC MODIFICATION
JO  - Artery Research
SP  - 59
EP  - 59
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.10.037
DO  - 10.1016/j.artres.2016.10.037
ID  - Catalano2016
ER  -