8.4 DIURNAL CHANGES IN CENTRAL PRESSURE AND PULSE WAVE PARAMETERS IN HEALTHY SUBJECTS

Bernhard Hametner; Christopher Mayer; Jelena Köster; Johannes Weber; Michael Reppel; Klaas Franzen; Eugenijus Kaniusas; Siegfried Wassertheurer; Kai Mortensen

doi:10.1016/j.artres.2016.10.060

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Volume 16, Issue C, December 2016, Pages 65 - 65

8.4 DIURNAL CHANGES IN CENTRAL PRESSURE AND PULSE WAVE PARAMETERS IN HEALTHY SUBJECTS

Authors

Bernhard Hametner¹, Christopher Mayer¹, Jelena Köster², Johannes Weber¹, Michael Reppel⁴, Klaas Franzen⁵, Eugenijus Kaniusas³, Siegfried Wassertheurer¹, Kai Mortensen⁶

¹AIT Austrian Institute of Technology, Health & Environment Department, Vienna, Austria

²Medical University of Schleswig-Holstein, Medical Clinic II, Lübeck, Germany

³Vienna University of Technology, Institute of Electrodynamics, Microwave and Circuit Engineering, Vienna, Austria

⁴Cardiology Landsberg, Landsberg, Germany

⁵Medical University of Schleswig-Holstein, Medical Clinic III, Lübeck, Germany

⁶Cardiology Practice, Kiel, Germany

Available Online 24 November 2016.

DOI

10.1016/j.artres.2016.10.060 How to use a DOI?

Abstract

Purpose: The feasibility of pulse wave analysis (PWA) over 24 hours with oscillometric devices has already been shown and first studies indicate additional information compared to single measurements. Nevertheless, diurnal patterns of PWA parameters in healthy subjects, which can potentially serve as a reference, are currently missing. Therefore, the aim of this study was to perform 24h-PWA measurements in healthy subjects over a wide age range and to analyse day/night differences.

Methods: 91 well defined healthy subjects underwent 24h PWA measurements using the Mobil-O-Graph device (IEM, Germany). The subjects were categorized in three age groups (20–29 years, 30–49 years, 50–69 years). Daytime (9–21h) and nighttime (0–6h) averages were calculated.

Results: A significant dipping behaviour in all age groups could be found for diastolic blood pressure (> 14 mmHg in all age groups, p<0.05), peripheral systolic blood pressure (> 15 mmHg, p<0.05) and central systolic blood pressure (> 9 mmHg, p<0.05). A significant rising effect in all age groups was found for the reflection magnitude (> 8 %). In contrast, the day/night difference in augmentation index was age dependent and this dependency remained also for AIx75, see table.

Conclusions: Prominent pressure dipping and a rise in reflection magnitude were present in all age groups during nighttime, while diurnal changes in augmentation index showed an age-dependency. This differing behaviour of PWA parameters should be investigated in further studies. Furthermore, the observed effects of diurnal changes in healthy subjects may provide a basis for reference profiles for future patient evaluation.

	20–29 years			30–49 years			50–69 years

	Day		Night	Day		Night	Day		Night
pSBP (mmHg)	118.8	^*	103.4	124.8	^*	109.0	123.0	^*	105.8
pDBP (mmHg)	75.7	^*	59.5	81.4	^*	64.2	79.6	^*	64.8
cSBP (mmHg)	106.3	^*	97.1	114.8	^*	103.3	114.5	^*	100.7
cDBP (mmHg)	77.4	^*	60.6	83.1	^*	65.3	81.1	^*	65.6
HR (bpm)	76.0	^*	59.6	77.5	^*	64.4	70.4	^*	59.8
AIx	18.2		19.0	19.7		22.7	25.9	^*	35.0
AIx75	19.3	^*	10.4	20.6		15.7	23.4		26.4
RM	55.2	^*	63.2	59.7	^*	68.8	62.3	^*	71.5

Table:

Mean day and night values for peripheral systolic blood pressure (pSBP), peripheral diastolic blood pressure (pDBP), central systolic blood pressure (cSBP), central diastolic blood pressure (cDBP), heart rate (HR), augmentation index (AIx, AIx75) and reflection magnitude (RM) ^* marks a significant difference between day and night (t-test, p<0.05).

Open Access

This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 16 - C
Pages: 65 - 65
Publication Date: 2016/11/24
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2016.10.060 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - Bernhard Hametner
AU  - Christopher Mayer
AU  - Jelena Köster
AU  - Johannes Weber
AU  - Michael Reppel
AU  - Klaas Franzen
AU  - Eugenijus Kaniusas
AU  - Siegfried Wassertheurer
AU  - Kai Mortensen
PY  - 2016
DA  - 2016/11/24
TI  - 8.4 DIURNAL CHANGES IN CENTRAL PRESSURE AND PULSE WAVE PARAMETERS IN HEALTHY SUBJECTS
JO  - Artery Research
SP  - 65
EP  - 65
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.10.060
DO  - 10.1016/j.artres.2016.10.060
ID  - Hametner2016
ER  -

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