Artery Research

Volume 16, Issue C, December 2016, Pages 61 - 62

6.10 PERIPHERAL SENSORY NEUROPATHY AND VASCULAR ANGIOGENIC FACTORS IN TYPE 2 DIABETES PATIENTS IN GHANA

Authors
Kwame Yeboah, Daniel A. Antwi, Ben Gyan
University of Ghana, Accra, Ghana
Available Online 24 November 2016.
DOI
10.1016/j.artres.2016.10.046How to use a DOI?
Abstract

Background: Impaired angiogenesis may be amongst the possible mechanism underlining the development of peripheral sensory neuropathy (PSN) in type 2 diabetes (T2DM) patients.(1) Angiogenesis is regulated by circulating vascular growth factor, notably, angiopoietin (Ang)-1, Ang-2 and vascular endothelial growth factor (VEGF).(2) We studied the relationship between PSN and circulating vascular growth factors, Ang-1, Ang-2 and VEGF in T2DM patients.

Method: PNS was assessed by vibration perception threshold (VPT) using Horwell’s neurothesiometer, and serum levels of Ang-1, Ang-2 and VEGF were also measured by Elisa in 107 T2DM patients and 93 nondiabetes subjects (controls). PNS was defined as VPT>25V.

Results: The overall prevalence of PNS was 11.2% higher in T2DM patients (10.1% vs. 1.1%, p=0.012) than controls. T2DM patients had higher mean VPT (12.1±7.8 vs. 7.3±3.8 V, p<0.001) than controls. Compared to those without PNS, PNS patients had lower Ang-2 levels [0.4 (0.2 – 0.8) vs. 0.8 (0.4 – 1.1) nmol/l, p=0.03] and higher VEGF levels [120 (60.8 – 254.4 vs. 59.4 (17.2 – 146.8), p=0.037], but no difference in Ang-1 levels. VPT was associated, positively with VEGF levels (r=0.22, p=0.003), and negatively with Ang-1 (r=−0.17, p=0.024), but not with Ang-2.

Discussion: Diabetes is associated with high prevalence of PNS and elevation of circulating vascular growth factors. PNS patients had imbalanced levels of circulating vascular growth factors, which may indicate impaired angiogenesis.

Open Access
This is an open access article distributed under the CC BY-NC license.

References

1.H Kim, JJ Kim, and Y-s Yoon, Emerging Therapy for Diabetic Neuropathy: Cell Therapy Targeting Vessels and Nerves, Endocrine, metabolic & immune disorders drug targets, Vol. 12, No. 2, 2012, pp. 168-78.
2.E Fagiani and G Christofori, Angiopoietins in angiogenesis, Cancer Lett, Vol. 328, No. 1, 2013, pp. 18-26. Epub 2012/08/28.
Journal
Artery Research
Volume-Issue
16 - C
Pages
61 - 62
Publication Date
2016/11/24
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2016.10.046How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Kwame Yeboah
AU  - Daniel A. Antwi
AU  - Ben Gyan
PY  - 2016
DA  - 2016/11/24
TI  - 6.10 PERIPHERAL SENSORY NEUROPATHY AND VASCULAR ANGIOGENIC FACTORS IN TYPE 2 DIABETES PATIENTS IN GHANA
JO  - Artery Research
SP  - 61
EP  - 62
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.10.046
DO  - 10.1016/j.artres.2016.10.046
ID  - Yeboah2016
ER  -