Artery Research

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Volume 16, Issue C, December 2016, Pages 66 - 67

8.7 CHANGES IN CARDIAC FUNCTION BUT NOT STRUCTURE IN HEALTHY SUBJECTS WITH PREMATURE VASCULAR AGEING

Authors
Oscar Mac Ananey1, Vincent Maher2
1School of Biological Science, Dublin Institute of Technology, Dublin, Ireland
2Department of Cardiology, Tallaght Hospital, Dublin, Ireland
Available Online 24 November 2016.
DOI
10.1016/j.artres.2016.10.063How to use a DOI?
Abstract

Purpose: Changes in myocardial and arterial wall properties/function are consistently reported in patients with established cardiovascular disease1. However, few studies have reported these changes in early subclinical disease. The aim of the present study was to examine cardiac and vascular changes in early subclinical disease and to determine whether these changes occur in parallel.

Methods: For this study, 98 healthy lifelong never smokers were recruited. Subjects were categorised as having normal (Norm, n=71) or abnormal (High. n=27) arterial stiffness (carotid-femoral pulse wave velocity, PWV Vicorder, Skidmore, UK) for their age and blood pressure. M-mode Doppler echocardiography (Vivid 7 Dimension, GE, USA) was used to assess heart structure (interventricular septal thickness, IVSd left ventricular internal diameter, LVIDd left ventricular posterior wall thickness, LVPW left ventricular mass, LV Mass) and function (left ventricular isovolumetric relaxation time, LV IVRT mitral valve early/late filling velocity, MV E/A).

Results: No differences in age (39+//0–9 v 39+//0–9 years P 0.87) or BMI (24.85+//0–3.29 v 25.75+//0–3.68 kg.m2 P 0.24) were observed. No differences in IVSd (0.86+//0–0.15 v 0.85+//0–0.18 cm P 0.64), LVIDd (4.98+//0–0.55 v 4.96+//0–0.42 cm P 0.95), LVPWd (0.81+//0–0.17 v 0.90+//0–0.21 cm P 0.05) or LV Mass (168.86+//0–56.85 v 182.61+//0–61.70 g P 0.43) were observed. However, MV E/A (1.85+//0–0.51 v 1.48+//0–0.51 P 0.0004), but not LV IVRT (0.09+//0–0.02 v 0.09+//0–0.01 P 0.25), was different.

Conclusions: Changes in cardiac function are observed before alterations in cardiac structure in healthy subjects with premature vascular stiffening.

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This is an open access article distributed under the CC BY-NC license.

References

1.AS Mansour, A Yannoutsos, N Majahalme, D Agnoletti, ME Safar, S Ouerdane, and J Blacher, Aortic stiffness and cardiovascular risk in type 2 diabetes, J Hypertens, Vol. 31, No. 8, 2013, pp. 1584-92.
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Journal
Artery Research
Volume-Issue
16 - C
Pages
66 - 67
Publication Date
2016/11/24
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2016.10.063How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Oscar Mac Ananey
AU  - Vincent Maher
PY  - 2016
DA  - 2016/11/24
TI  - 8.7 CHANGES IN CARDIAC FUNCTION BUT NOT STRUCTURE IN HEALTHY SUBJECTS WITH PREMATURE VASCULAR AGEING
JO  - Artery Research
SP  - 66
EP  - 67
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.10.063
DO  - 10.1016/j.artres.2016.10.063
ID  - MacAnaney2016
ER  -