Artery Research

Volume 16, Issue C, December 2016, Pages 68 - 68

8.11 CARDIO-ANKLE VASCULAR INDEX AND CAROTID-FEMORAL PULSE WAVE VELOCITY ARE CLOSELY ASSOCIATED WITH CHRONOLOGICAL AGE

Authors
L.B. Mendes1, 2, 3, E. Bunting3, K. Ali2, 3, J. Timeyin3, C. Rajkumar2, 3
1Universidade Federal do Ceará, Fortaleza, Brazil
2Brighton and Sussex Medical School, Brighton, UK
3Brighton and Sussex University Hospitals Trust, Brighton, UK
Available Online 24 November 2016.
DOI
10.1016/j.artres.2016.10.067How to use a DOI?
Abstract

Background: Vascular stiffening is part of the ageing process. However, it is not clear which vascular stiffness parameters are closely associated with chronological age.

Methods: Fifty-eight participants (38 men), age 69.57 ± 10.46 (mean ± SD, range = 47–90 years) who have had transient ischaemic attack or lacunar stroke within the last 2 weeks, had vascular stiffness parameters, brachial and central blood pressures measured. Cardio-ankle vascular index (CAVI) was measured with VaSera VS-1500N® (Fukuda Denshi, Japan); carotid-femoral pulse wave velocity (cfPWV) and carotid-radial pulse wave velocity (crPWV) were measured with Complior® (ALAM Medical, France); radial augmentation index (rAIx) and central blood pressure were measured with SphygmoCor® (AtCor, Australia).

Results: The mean and standard error of the mean for each parameter (mean ± SEM) was as follows: CAVI=9.77 ± 0.21, cfPWV = 10.61 ± 0.46 m/s, crPWV = 11.05 ± 0.30 m/s, rAIx = 31.34 ± 1.60 %, and central pulse pressure (cPP) = 50.22 ± 1.81 mmHg. In a bivariate analysis, CAVI (r = 0.59, p<0.01) and cfPWV (r = 0.39, p<0.01) were significantly associated with age, but rAIx (r = 0.12, p = 0.371) and crPWV (r = 0.06, p=0.682) were not. A multivariate regression analysis, performed with age as the dependent factor and CAVI, cfPWV, crPWV, cPP, and rAIx as independent parameters, showed that CAVI was the only significant parameter (β = 0.49, p = 0.002) associated with age.

Conclusion: CAVI and cfPWV are closely associated with chronological age, whereas crPWV and rAIx are less so. We suggest that the vascular parameter which best predicts biological age is CAVI, followed closely by cfPWV.

Open Access
This is an open access article distributed under the CC BY-NC license.

Journal
Artery Research
Volume-Issue
16 - C
Pages
68 - 68
Publication Date
2016/11/24
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2016.10.067How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - L.B. Mendes
AU  - E. Bunting
AU  - K. Ali
AU  - J. Timeyin
AU  - C. Rajkumar
PY  - 2016
DA  - 2016/11/24
TI  - 8.11 CARDIO-ANKLE VASCULAR INDEX AND CAROTID-FEMORAL PULSE WAVE VELOCITY ARE CLOSELY ASSOCIATED WITH CHRONOLOGICAL AGE
JO  - Artery Research
SP  - 68
EP  - 68
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.10.067
DO  - 10.1016/j.artres.2016.10.067
ID  - Mendes2016
ER  -