Artery Research

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Volume 16, Issue C, December 2016, Pages 75 - 75

11.4 RELATIONSHIP BETWEEN INFLAMMATORY CYTOKINES AND AORTIC STIFFNESS IN PATIENTS WITH CHRONIC KIDNEY DISEASE

Authors
Marie-Pier Desjardins, Aboubacar Sidibe, Catherine Fortier, Sacha De Serres, Richard Larivière, Mohsen Agharazii
Centre de Recherche du CHU de Quebec, Division of Nephrology, Faculty of Medicine, Université Laval, Quebec City, Canada
Available Online 24 November 2016.
DOI
10.1016/j.artres.2016.10.092How to use a DOI?
Abstract

Introduction: Cardiovascular diseases are the primary cause of morbidity and mortality in patients with chronic kidney disease (CKD). Aortic stiffness is a non-traditional risk factor in these patients. Using an animal model of CKD with vascular calcification, we reported that inflammation is involved in the development of aortic calcification and stiffness. Hence, increased vascular production of IL-1β, IL-6 and TNFα was associated with aortic calcification. Therefore, we investigated the impact of the latter cytokines on aortic stiffness and determined the profile of inflammatory cytokines in a cohort of CKD patients.

Methods: This is a transversal study involving 196 CKD patients on dialysis, in which aortic stiffness was determined non-invasively by the assessment of carotid-femoral pulse wave velocity (cf-PWV) using Complior SP (Artech Medical, Pantin, France). The profile of inflammatory cytokines (IFNv, IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12 and TNF α) was determined in plasma by ELISA using a Multiplex (Aushon, Maine, USA).

Results: Mean cf-PWV of the cohort was 12.8±3.9 m/s. Median plasma levels of IL-1β, IL-6 and TNFα were 1.01 pg/ml, 4.26 pg/ml and 3.33 pg/ml, respectively. IL-6 levels positively correlated with cf-PWV (β = 0.218, P = 0.006, R = 0.129), suggesting a role in aortic stiffness. In contrast, no correlation between PWV and plasma levels of IL-1β or TNFα was established.

Conclusion: This study reveals a relationship between an inflammatory cytokine, Il-6, and aortic stiffness in patients with CKD. Our results, together with our previous findings in an experimental animal model, indicate that IL-6 may represent a novel therapeutic target of cardiovascular diseases in CKD.

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References

1.M AGHARAZII et al., Inflammatory Cytokines and Reactive Oxygen Species as Mediators of Chronic Kidney Disease-Related Vascular Calcification, American Journal of Hypertension, Vol. 28, 2015, pp. 746-55.
2.AS GO et al., Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization, N Engl J Med, Vol. 351, 2004, pp. 1296-1305.
3.PS PARFREY et al., Clinical epidemiology of cardiac disease in chronic renal failure, J Am Soc Nephrol, Vol. 10, 1999, pp. 1606-15.
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Journal
Artery Research
Volume-Issue
16 - C
Pages
75 - 75
Publication Date
2016/11/24
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2016.10.092How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Marie-Pier Desjardins
AU  - Aboubacar Sidibe
AU  - Catherine Fortier
AU  - Sacha De Serres
AU  - Richard Larivière
AU  - Mohsen Agharazii
PY  - 2016
DA  - 2016/11/24
TI  - 11.4 RELATIONSHIP BETWEEN INFLAMMATORY CYTOKINES AND AORTIC STIFFNESS IN PATIENTS WITH CHRONIC KIDNEY DISEASE
JO  - Artery Research
SP  - 75
EP  - 75
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.10.092
DO  - 10.1016/j.artres.2016.10.092
ID  - Desjardins2016
ER  -