Environment and Objectives: Obesity is linked to a higher prevalence of risk factors, metabolic and inflamatory pathways conducting to increased vascular disease and CV risk.

To assess vascular disarrangements using non invasive methods in obese subjects (O) compared with matched lean (L) controls.

Methods: From the database of our Non Invasive Vascular Lab with 3964 first evaluated patients, we performed a case control study with 363 subjects, 268 obese and 95 lean age and sex matched controls. We measured IMT, Plaque analysis, PWV, Endothelial Function (EF) and arterial stiffness (CAP and Aix) (AS) using an oscillometric device (Arteriograph, Tendiomed. Hungary).

Results: Age (O 42.5+5 L 43.5+11) and sex % (O 80.6% L 78%) were similar. BMI (O 33.5+3.3 L 25+1.1Kg/m2), waist (O110.4+7.5 L 91.2+6.1cm) and BP (SBP O 139.8+16.8 L119+8.8 and DBP O 89+3.9 L 74.3+8 mmHg) were higher in O (p<0.001).CV Risk Factors in O: HTN 68% DLP 59.7% SMKG 24.2% DBT2 7.8% SED 72.4%. The proportion of abnormalities in IMT (O/L : 65.8/25.3%), Plaques (75.6/38.9%), EF (57.5/33.7%)and PWV (41.4/17.9%) were higher in O (p<0.001).Central and Peripheral PP were higher in O but not Aix.

Conclusion: Obese patients present a higher prevalence of vascular disarrangements although structural and functional explaining the role of this condition as a CV risk factor .