Artery Research

Volume 16, Issue C, December 2016, Pages 88 - 88

15.11 TOWARDS NONINVASIVE CARDIAC CATHETERISATION

Authors
Maarten Heusinkveld1, Joost Lumens1, Katherine March2, Arthur Bouwman3, Tammo Delhaas1, Alun Hughes2, Koen Reesink1
1CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, Netherlands
2Institute of Cardiovascular Science, University College London, UK
3Department of Anaesthesiology, Catherina Hospital, Eindhoven, Netherlands
Available Online 24 November 2016.
DOI
10.1016/j.artres.2016.10.142How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Background: Doppler echocardiographic measures of diastolic function, such as E/e’ are correlates of left ventricular (LV) end-diastolic pressure (ped) and diastolic compliance (Cd) [1]. We developed a noninvasive computational approach to obtain these essential markers of LV diastolic abnormalities and tested it against the invasive gold standard.

Methods: In patients undergoing coronary angiography (n=8, age 60+/−13yrs, with no atrial fibrillation or other dysrhythmia), we obtained mitral and aortic valve Doppler tracings, LV wall thickness and cavity volumes, brachial systolic and diastolic blood pressure (BP) and, for validation purposes, LV pressure and volume invasively by conductance catheter. Repeated echocardiography and BP measurements were performed at baseline conditions and averaged. Catheter measurements were performed during baseline and Valsalva manoeuvre. The latter causes a change in LV preload, enabling a robust estimation of Cd. We fitted a computational model describing the cardiovascular circulation (CircAdapt, www.circadapt.org) to the noninvasively measured data. Catheter measurements served as a reference to validate model-predicted ped and Cd.

Results: Catheter-measured ped was found to be 21+/−6mmHg (mean+/−SD, n=8) and Cd was 3.1+/−3.0ml/mmHg (n=6). The bias and limits of agreement between the model-estimated and catheter-measured ped and Cdwere −0.9+/−7.5mmHg and 1.1+/−2.6ml/mmHg, respectively.

Conclusions: We found reasonable agreement between our noninvasive modelling-based method of estimating ped and Cd and catheter measurements. Due to its noninvasiveness, our method could be useful for detection of LV diastolic abnormalities in more patients and settings. Next, we will investigate how measurement errors propagate into the uncertainty of model predictions of ped and Cd.

References

1.Sherif F Nagueh et al., Doppler tissue imaging: a noninvasive technique for evaluation of left ventricular relaxation and estimation of filling pressures, Journal of the American College of Cardiology, Vol. 30, No. 6, 1997, pp. 1527-1533.
Journal
Artery Research
Volume-Issue
16 - C
Pages
88 - 88
Publication Date
2016/11/24
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2016.10.142How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Maarten Heusinkveld
AU  - Joost Lumens
AU  - Katherine March
AU  - Arthur Bouwman
AU  - Tammo Delhaas
AU  - Alun Hughes
AU  - Koen Reesink
PY  - 2016
DA  - 2016/11/24
TI  - 15.11 TOWARDS NONINVASIVE CARDIAC CATHETERISATION
JO  - Artery Research
SP  - 88
EP  - 88
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.10.142
DO  - 10.1016/j.artres.2016.10.142
ID  - Heusinkveld2016
ER  -