Artery Research

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Volume 16, Issue C, December 2016, Pages 91 - 92

PO-10 VASCULAR FUNCTION IN INDIVIDUALS WITH DOWN SYNDROME

Authors
Sang Ouk Wee, Alexander J. Rosenberg, Kanokwan Bunsawat, Garett Griffith, Tracy Baynard, Bo Fernhall
University of Illinois at Chicago, Chicago, IL, United States
Available Online 24 November 2016.
DOI
10.1016/j.artres.2016.08.018How to use a DOI?
Abstract

Individuals with Down syndrome (DS) experience premature aging. Arterial stiffness increases with advancing biological age and predicts cardiovascular disease. However, only limited studies investigated arterial function in individuals with DS. Thus, the impact of DS on vascular function still remains poorly understood.

Purpose: To compare vascular function between individuals with and without DS (control).

Methods: Twenty-seven volunteers (DS=13, Control=14) participated in this study. Central arterial stiffness indices (β-stiffness, Ep and circumferential strain) were measured by carotid ultrasonography and analyzed with B-mode, echo tracking and strain analysis. Cardio-ankle Vascular Index (CAVI) and carotid blood pressure (carBP) were measured using a limb cuff system and applanation tonometry (SphygmoCor), respectively. In addition, heart rate (HR) was recorded by finger photoplethymography.

Results: There were significant differences in CAVI (lower) and circumferential strain (higher) in individuals with DS compared to individuals without DS (p<0.05). No group differences were observed for β-stiffness and Ep.

Conclusions: Our results suggest that individuals with DS have lower arterial stiffness than that of individuals without DS. Interestingly, circumferential carotid strain was greater in persons with DS, with no differences in β-stiffness, suggesting the greater strain may have been a function of greater pulse pressure in individuals with DS.

DS (N = 13) Control (N = 14)
carSBP (mmHg) 133 ± 22 126 ± 14
carDBP (mmHg) 74 ± 8 75 ± 9
HR (bmp) 62.5 ± 11.9 64.3 ± 13.1
Circumferential Strain ‡ 9.94 ± 3.37 7.48 ± 2.56
R-CAVI ‡ 4.86 ± 0.83 5.84 ± 0.68
L-CAVI ‡ 4.97 ± 0.95 5.81 ± 0.68
β-Stiffness 5.24 ± 1.40 5.65 ± 1.99
Ep 72.38 ± 20.84 76.29 ± 20.48
‡

Significant group difference. Mean ± SD, Significance level, p < 0.05

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
16 - C
Pages
91 - 92
Publication Date
2016/11/24
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2016.08.018How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Sang Ouk Wee
AU  - Alexander J. Rosenberg
AU  - Kanokwan Bunsawat
AU  - Garett Griffith
AU  - Tracy Baynard
AU  - Bo Fernhall
PY  - 2016
DA  - 2016/11/24
TI  - PO-10 VASCULAR FUNCTION IN INDIVIDUALS WITH DOWN SYNDROME
JO  - Artery Research
SP  - 91
EP  - 92
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.08.018
DO  - 10.1016/j.artres.2016.08.018
ID  - Wee2016
ER  -