Artery Research

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Volume 16, Issue C, December 2016, Pages 97 - 98

PO-32 DIETARY CALCIUM INTAKE AND CARDIOVASCULAR HEALTH: IS THERE ANY RELATIONSHIP?

Authors
Shubhabrata Das1, 2, Yessica-Haydee Gomez2, David Goltzman3, Angel M. Ong2, 4, Yessica H. Gomez2, Jessica Gorgui5, Michelle Wall2, Suzanne N. Morin2, 6, Stella S. Daskalopoulou1, 2, 6
1Division of Experimental Medicine, Department of Medicine, McGill University, Montreal, Canada
2Cardiovascular Health Across Lifespan Program, Research Institute of the McGill University Health Centre, McGill University Health Centre Research Institute, Montreal, Canada
3Departments of Medicine and Physiology, McGill University, Montreal, Canada
4School of Dietetics and Human Nutrition, McGill University, Sainte-Anne-de-Bellevue, Canada
5Department of Pharmaceutical Science, Faculty of Pharmacy, Université de Montréal, Montreal, Canada
6Division of Internal Medicine, Department of Medicine, McGill University, Montreal, Canada
Available Online 24 November 2016.
DOI
10.1016/j.artres.2016.08.035How to use a DOI?
Abstract

Introduction: Calcium intake, recommended for osteoporosis prevention, has been associated with cardiovascular (CV) outcomes. We examined the association of dietary calcium intake (dCa) with surrogate CV markers, including carotid intima-media thickness (cIMT), arterial stiffness and hemodynamics in healthy postmenopausal women.

Methods: Healthy postmenopausal women without any CV risk factors, from a randomized controlled trial studying the effect of calcium supplementation vs. dietary calcium on vascular heath, were recruited. Cross-sectional analyses of baseline data of the participants are presented. Peripheral systolic and diastolic blood pressures (pSBP, pDBP) were measured by BpTRU. cIMT of both common-carotid arteries was measured by B-mode ultrasonography (Philips-iU22). Arterial stiffness (carotid-to-femoral pulse wave velocity [cfPWV] and carotid-to-radial PWV), central SBP and DBP (cSBP, cDBP), mean arterial pressure (MAP), and hemodynamic parameters (pulse pressure, augmentation pressure, augmentation index corrected for 75 bpm) were obtained non-invasively (SphygmoCor). Usual dCa intake was estimated using a validated food frequency questionnaire. Measurements were compared across groups (<600, 600–1000 and >1000 mg/day of dCa) by one-way analysis of variance and covariance.

Results: We evaluated 83 postmenopausal women (mean age 60.4±6.3 years; BMI 25.6±3.8 kg/m2). Mean dCa was 857±333 mg/day. Although within normal range, vascular parameters had a non-significant, U-shaped relationship with dCa. In unadjusted analyses, women with dCa >1000 mg/day had significantly higher cfPWV, pSBP, cSBP, and MAP compared to those with 600–1000 mg/day; however, significance was lost for all other parameters except for MAP after adjustment for pertinent covariates (Table).

Conclusion: In healthy postmenopausal women, a non-significant, U-shaped relationship of vascular parameters across the 3 dCa groups was noted; dietary calcium may have favourable effect on MAP for those consuming 600–1000 mg/day compared to >1000 mg/day intake. Of note, our population had optimal/normal BP. Our ongoing study including a larger sample-size will determine the relationship between dCa and surrogate CV markers.

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
16 - C
Pages
97 - 98
Publication Date
2016/11/24
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2016.08.035How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Shubhabrata Das
AU  - Yessica-Haydee Gomez
AU  - David Goltzman
AU  - Angel M. Ong
AU  - Yessica H. Gomez
AU  - Jessica Gorgui
AU  - Michelle Wall
AU  - Suzanne N. Morin
AU  - Stella S. Daskalopoulou
PY  - 2016
DA  - 2016/11/24
TI  - PO-32 DIETARY CALCIUM INTAKE AND CARDIOVASCULAR HEALTH: IS THERE ANY RELATIONSHIP?
JO  - Artery Research
SP  - 97
EP  - 98
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.08.035
DO  - 10.1016/j.artres.2016.08.035
ID  - Das2016
ER  -