P1.03 LEFT VENTRICULAR REMODELING: IMPACT OF GLOBAL, REGIONAL AND LOCAL AORTIC STIFFNESS
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- 10.1016/j.artres.2013.10.034How to use a DOI?
- Abstract
Objectives: Left ventricular (LV) concentric remodeling predicts all cause and CV mortality in various subsets of patients. Large arteries stiffness determines cardiac afterload and therefore LV remodeling. Since elastic properties of the arterial wall vary along the aortic pathway, we hypothesized that stiffness of consecutive aortic segments could have different impact on LV remodeling.
Methods: Global aortic stiffness was obtained from carotid-femoral pulse wave velocity (cfPWV, m/s) aplanation tonometry (Pulse Pen), and regional stiffness from aortic arch PWV phase contrast MRI. Local stiffness (m/s) was calculated in ascending (aaPWV) and descending aorta (daPWV) using cine MRI acquisition and surface change estimation (Bramwell-Hill equation). LV remodeling, MRI estimated, was expressed as LV mass over end diastolic volume ratio (M/V).
Results: We evaluated 146 patients (41±15 years old; 43.8% women) free of overt CV disease (hypertensives: 9.6%; smokers: 8.9%; diabetics: 0.6%; BMI: 23.8±3.5). In multivariate regression analysis cfPWV and aaPWV strongly correlated to M/V (partial R2=0.07, p=0.0011; and partial R2=0.10, p=0.0001, respectively), after adjustment for age, sex, BMI and brachial MBP. Challenged together, both cfPWV and aaPWV independently determined M/V, with 5% and 8% of explained variance, respectively. To a lower extent, daPWV (Partial R2= 0.04, p=0.0115) was also independently related to M/V. Arch PWV was not independently associated with M/V.
Conclusions: In this cross-sectional study, stiffness of diverse segments of the aorta had different influence on LV remodeling, except arch PWV. Stiffness of ascending aorta and the carotid-femoral pathway were complementary and also the strongest explanatory variables for LV remodeling.
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Cite this article
TY - JOUR AU - T.Q.S. Quinaglia AU - M.Z.B. Bensalah AU - E.B. Bollache AU - N.K. Kachenoura AU - L.M. Macron AU - P.B. Boutouyrie AU - S.L. Laurent AU - E.M. Mousseaux PY - 2013 DA - 2013/11/11 TI - P1.03 LEFT VENTRICULAR REMODELING: IMPACT OF GLOBAL, REGIONAL AND LOCAL AORTIC STIFFNESS JO - Artery Research SP - 111 EP - 111 VL - 7 IS - 3-4 SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2013.10.034 DO - 10.1016/j.artres.2013.10.034 ID - Quinaglia2013 ER -