P3.21 CENTRAL HEMODYNAMICS PARAMETERS IN BLACK HYPERTENSIVE PATIENTS BORN AND LIVING IN SUB-SAHARAN AFRICA
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- 10.1016/j.artres.2013.10.108How to use a DOI?
- Abstract
Background: Few studies assessed arterial stiffness in Black hypertensive patients Born and living in sub-Saharan Africa, where cardiovascular disease reaches epidemic proportions.
Methods: The Newer versus Older Antihypertensive Agents in African Hypertensive Patients (NOAAH) trial had recruited native African patients to compare the efficacy of various Antihypertensive drugs given once daily as single-pill combinations. Two centers engaged in Pulse wave analysis and measured carotid femoral pulse wave velocity (PWV). Statistical Methods included single and multiple linear regressions.
Results: Of 172 patients screened, 116 entered the ancillary study on central hemodynamics (51.3% women; mean age 52.7 years; untreated blood pressure 147.6/87.1 mm Hg).the augmentation indexes were higher (p<0.0001) in women than men, both peripherally (pAI, 11.1 vs.10.6%) and centrally (cAI, 39.0 vs. 28.0%). PWV (8.91 m/s) and central pulse pressure (cPP, 48.7 mm Hg) were similar (p>0.844) in both sexes. pAI and cAI increased with female sex and mean arterial pressure, but decreased with heart rate and body mass index. cPP increased with age and mean arterial pressure. PWV increased with age and mean arterial pressure. Patients with measurements above the age-specific thresholds determined in healthy Black South Africans amounted to 0 for cAI, 1 (1.2%) for cPP, and 11 (18.3%) for PWV.
Conclusion: NOAAH patients have measures of arterial stiffness similar to those of a healthy Black reference population with determinants as reported in the literature. Our observations Highlight the potential for the prevention of irreversible arterial damage by timely treating Sub-Saharan hypertensive patients to target blood pressure levels.
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Cite this article
TY - JOUR AU - M.K. Kamdem AU - E.A. Birinus AU - D. Lemougoum AU - B.C. Anisiuba AU - J. Kaptue AU - J. Staessen AU - M’buyamba Rene AU - A. Odili PY - 2013 DA - 2013/11/11 TI - P3.21 CENTRAL HEMODYNAMICS PARAMETERS IN BLACK HYPERTENSIVE PATIENTS BORN AND LIVING IN SUB-SAHARAN AFRICA JO - Artery Research SP - 132 EP - 132 VL - 7 IS - 3-4 SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2013.10.108 DO - 10.1016/j.artres.2013.10.108 ID - Kamdem2013 ER -