Clinical Hematology International

Volume 1, Issue 1, March 2019, Pages 10 - 18

Management of AML Beyond “3 + 7” in 2019

Authors
Jonathan Canaani*
Hematology Division, Chaim Sheba Medical Center, Tel Hashomer, Israel

Peer review is under the responsibility of IACH

Corresponding Author
Jonathan Canaani
Received 11 February 2019, Accepted 6 March 2019, Available Online 18 March 2019.
DOI
https://doi.org/10.2991/chi.d.190316.001How to use a DOI?
Keywords
Acute myeloid leukemia; Targeted agents; FLT3; bcl-2; IDH1; IDH2
Abstract

The therapeutic paradigm for treatment of acute myeloid leukemia (AML) is rapidly changing with the advent of a new generation of drugs targeting diverse aspects of leukemogenesis. Whereas standard treatment for AML until recently consisted of a classic chemotherapy backbone, the incorporation of novel agents targeting pathogenic mutations, myeloid surface markers, and apoptosis-related proteins may become a reality in the next few years. In this review, we outline the therapeutic landscape of recently approved novel agents for AML, including FLT3 inhibitors, isocitrate dehydrogenase 1/2 (IDH1/2) inhibitors, Bcl-2 antagonists, hedgehog signaling inhibitors, and immunotherapy-based approaches. Some of the future challenges in the field would be to delineate which specific patient subsets derive the most clinical benefit from a given novel agent and, furthermore, which drug combinations will yield the maximal antileukemia effect without increased toxicity. To this end, it is expected that advances in genomic and epigenomic classification of AML will facilitate a rational and optimal choice of these novel agents for AML patients.

Copyright
© 2019 International Academy for Clinical Hematology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal
Clinical Hematology International
Volume-Issue
1 - 1
Pages
10 - 18
Publication Date
2019/03/18
ISSN (Online)
2590-0048
DOI
https://doi.org/10.2991/chi.d.190316.001How to use a DOI?
Copyright
© 2019 International Academy for Clinical Hematology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - JOUR
AU  - Jonathan Canaani
PY  - 2019
DA  - 2019/03/18
TI  - Management of AML Beyond “3 + 7” in 2019
JO  - Clinical Hematology International
SP  - 10
EP  - 18
VL  - 1
IS  - 1
SN  - 2590-0048
UR  - https://doi.org/10.2991/chi.d.190316.001
DO  - https://doi.org/10.2991/chi.d.190316.001
ID  - Canaani2019
ER  -